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Diss Factsheets
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EC number: 231-992-5 | CAS number: 7783-35-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of PCBs, DDT, and Mercury Compounds upon Egg Production, Hatchability and Shell Quality in Chickens and Japanese Quail
- Author:
- M. L. SCOTT, J. R. ZIMMERMANN, SUSAN MARINSKY AND P. A. MULLENHOFF, G. L. RUMSEY AND R. W. RICE
- Year:
- 1 975
- Bibliographic source:
- Poultry sciences,1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per below
- Principles of method if other than guideline:
- The developmental study of chicken were studied and chickens was treated for 8 weeks with 100 and 200 mg/kg concentration of mercury sulphate.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Mercury sulphate
- EC Number:
- 231-992-5
- EC Name:
- Mercury sulphate
- Cas Number:
- 7783-35-9
- Molecular formula:
- H2O4S.Hg
- IUPAC Name:
- mercury sulfate
- Details on test material:
- - Name of test material: Mercury sulphate
- Molecular formula: H2O4S.Hg
- Molecular weight : 298.67 g/mol
- Smiles notation: [O-]S(=O)(=O)[O-].[Hg+2]
- InChl : InChI=1S/Hg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
- Substance type: Solid
- Physical state: Inorganic
- Impurities (identity and concentrations): No data
Constituent 1
Test animals
- Species:
- other: Chickens
- Strain:
- other: White Leghorn
- Details on test animals or test system and environmental conditions:
- Details on test animal & Environmental conditions
TEST ANIMALS
- Source: No data available
- Age at study initiation: 12-1/2 months of age.
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): 3.5% calcium Diet A (ad libitum)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: feed
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: Feed
- Details on exposure:
- No data available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data available
- Details on mating procedure:
- No data available
- Duration of treatment / exposure:
- 8 weeks
- Frequency of treatment:
- Daily
- Duration of test:
- 100 and 200 mg/kg
- No. of animals per sex per dose:
- One hundred and eighty hens housed in individual cages were divided into nine sets of four groups of five hens per group to receive each treatment.
- Details on study design:
- No data available
Examinations
- Maternal examinations:
- No data available
- Ovaries and uterine content:
- No data available
- Fetal examinations:
- No data available
- Statistics:
- No data available
- Indices:
- No data available
- Historical control data:
- No data available
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes. Remark: Feed intake of the hens, changes in average body weights and percent egg production for each treatment over an 8 week experimental period
Effect levels (maternal animals)
- Dose descriptor:
- LOAEL
- Effect level:
- 200 mg/kg diet
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
Mercuric sulfate appeared to have only a slight effect upon egg weights, egg size.
Mercuric sulfate had no effect upon the relative distribution of yolk, albumen and shell.
The hatchability of fertile eggs collected during the seventh week was decreased somewhat by the mercuric sulfate.
The decreases in shell quality for the first eggs in the clutch were not severe,
whereas the second eggs showed significant decreases in shell thickness with the dietary treatment of both 200 p.p.m. of mercuric sulfate
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The endpoint of development study for mercury sulphate(7783-35-9) was found to be LOAEL at 200 mg/kg.
- Executive summary:
The developmental study of chicken were studied and chickens was treated for 8 weeks with 100 and 200 mg/kg concentration of mercury sulphate. One hundred and eighty hens housed in individual cages were divided into nine sets
of four groups of five hens per group to receive each treatment. Feed and water were supplied ad libitum. The basal diet was the 3.5% calcium Diet A.Egg production was recorded daily, feed intake measured every two weeks, and eggshell
quality determined at biweekly intervals.Feed intake of the hens, changes in average body weights and percent egg production for each treatment over an 8 week experimental period.
Mercuric sulfate appeared to have only a slight effect upon egg weights, egg size. Mercuric sulfate had no effect upon the relative distribution of yolk, albumen and shell. The hatchability of fertile eggs collected during the seventh week was decreased somewhat by the mercuric sulfate.The decreases in shell quality for the first eggs in the clutch were not severe,whereas the second eggs showed significant decreases in shell thickness with the dietary treatment of both 200mg/kg of mercuric sulfate.
Therefore, theendpoint of development study for mercury sulphate (7783-35-9) was found to be LOAEL at 200 mg/kg.
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