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Diss Factsheets
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EC number: 233-245-9 | CAS number: 10099-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Lead dinitrate does not exhibit toxicity in acute toxicity tests with experimental animals. No test results were required for acute toxicity via the inhalation and dermal route because only 0.03% of the lead dinitrate particles are within the inhalable size limits (<10 µm) and therefore an acute inhalation test is not required (see IUCLID section 4.5 for discussion of the complete dustiness test) and because Pb shows a low skin absorption, respectively.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Klimisch 1 and Klimisch 2 studies.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Although lead can exert toxic effects upon multiple organ systems and body functions, this toxicity manifests under conditions of sub-chronic to chronic exposure that can range from months to years in duration. Acute toxicity is not observed in animals after oral lead dinitrate exposures up to the limit values of acute toxicity testing (2000 mg/kg bw). Inhalation and dermal exposure of lead dinitrate were considered not relevant because of the absence of particles within the inhalable size range.
This finding is not unexpected given the pharmacokinetics of lead uptake into the body. Lead uptake is generally quite low and heavily reliant upon easily saturable active transport mechanisms. Once saturation of these uptake mechanisms has occurred, uptake proceeds by inefficient passive diffusion. The uptake of lead is thus highly non-linear as a function of dose with uptake efficiency declining with the amount of lead administered to a test animal or an exposed human. Although toxic under chronic exposure situations, the acute toxicity of lead oxide is low.
Justification for selection of acute toxicity – oral endpoint
No one study is selected because there are several Klimisch 2 studies.
Justification for selection of acute toxicity – dermal endpoint
No one study is selected because there are three Klimisch 2 studies conducted with read across substances.
Justification for classification or non-classification
The current classification of lead compounds not otherwise described in Annex I is:
Xn; R20/22 (harmful by inhalation and if swallowed)
and under CLP:
Acute Tox. 4 * (H332)
Acute Tox. 4 * (H302)
Acute toxicity is not observed in animals after oral exposures up to the limit values of acute toxicity testing for a similar lead salt, i.e. lead acetate. However lead dinitrate is classified as Acute Tox. Cat. 4 (H302) according to the official classification for lead compounds in regulation (EC) 1272/2008, which is a worst-case, precautionary approach.
Only 0.03% of the lead dinitrate particles are within the inhalable size limits (<10 µm) and therefore an acute inhalation test is not required. However, the official lead compounds classification is for the inhalation route Acute Tox. Cat. 4 (H332)
Since lead has a low skin absorption (Moore et al., 1980), testing by the dermal route is inappropriate (see waiver IUCLID section 7.2.3). Lead dinitrate is therefore not classified for Acute Tox. Cat. 4 dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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