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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 278-355-8 | CAS number: 75980-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The content of the test item was determined by a validated method of high performance liquid chromatography with DAD detection [SPR/C/216].
In the definitive test from each test concentration and the control the samples of fresh solutions were taken at exposure initiation and the samples of old solutions were taken at exposure termination (i.e. pooled replicates) [SOP/W/83]. - Details on test solutions:
- An undiluted filtrate of a loading of 100 mg/L and its 2-, 4-, 8- and 16-fold dilutions with the test medium plus the control were tested.
In the definitive test 125.09 mg of the test item was weighed into a glass flask (analytical balance SBC22, Scaltec) [SOP/W/7] and quantitatively transferred into a glass flask by multiple washing with test medium in a total volume of 1250 mL. The mixture was heterogeneous with visible not dissolved
parts of the test item. Therefore, the mixture was heated for 2 hours at 50oC in a water bath and then sonicated for 30 min (ultrasonic bath, Sonic-10, Polsonic [SOP/W/78]). The non-dissolved part of the mixture was separated by filtration thorough a conditioned nitrocellulose membrane filter (filter type HAWG, 0.45 Xm pores, Millipore) [SOP/W/37]. The filtrate was a homogeneous and transparent solution and was used as the highest test concentration. The lower test concentrations were prepared by sequential dilutions with the test medium in a ratio 1 : 1, volume per volume (as given in Table 1). The generated solutions were treatments named: an undiluted filtrate of a loading of 100 mg/L and its 2-fold dilution, 4-fold dilution, 8-fold dilution and 16-fold dilution. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus (< 24 h old at test initiation), not first brood progeny, range of parent daphnid age: 21 – 25 days, neonates collected from
laboratory culture in the Institute of Industrial Organic Chemistry Branch Pszczyna, Department of Ecotoxicology, Laboratory of Aquatic Toxicology. - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Test temperature:
- 21.2 – 21.7°C
- pH:
- 7.69 - 7.97
- Dissolved oxygen:
- 8.5 - 9.2
- Nominal and measured concentrations:
- nominal [mg/L] - measured [average, mg/L]
control - 0.000
0.5 - 0.429
1.0 - 0.840
10.0 - 8.063 - Details on test conditions:
- daily cycle: 16 h light : 8 h darkness without illumination by fluorescent light source, no feeding, no aeration.
- Reference substance (positive control):
- no
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.53 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Results with reference substance (positive control):
- EC50 = 0.63 mg/L
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.53 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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