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Diss Factsheets
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EC number: 203-192-6 | CAS number: 104-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
NOAEL reproductive toxicity Chlorphenesin = 100 mg/ kg bw/day base on WoE approach.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Studies conducted according to internationally accepted testing guidelines.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The assessment for toxicity to reproduction of Chlorphenesin is based on weight of evidence approach using the data obtained by 28 days repeated oral toxicity study performed in 1990 and by prenatal developmental toxicity study in 1994.
- In 28 days repeated oral toxicity study Chlorphenesin was administered orally to rats at dosage levels of 1000, 100 and 10 mg/kg bw/day. No effect on reproductive organs was recorded .
- In prenatal developmental toxicity study Chlorphenesin was tested to evaluate the effect of on pregnancy and in utero development of the rat. Doses of 0 (Control), 10, 50 and 100 mg/kg were administered to groups of twenty-five females, by oral gavage once per day, from Days 6 to 15 post coitum inclusive. The number of non pregnant rats and as well as the ratio No. of implantation/ No. of corpora lutea of the control group were comparable to values found for the treated groups.
As conclusion NOEL reproductive toxicity of Chlorphenesin= 100 mg/kg bw/day.
Effects on developmental toxicity
Description of key information
NOEL developmental toxicity Chlorphenesin = 100 mg/ kg bw/day
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via dermal route
- Quality of whole database:
- Study conducted according to internationally accepted testing guidelines.
Additional information
In vivo test regarding developmental toxicity of Chlorphenesin was performed in 1994, before the implementation of the Regulation (EC n.1223/2009). Chlorphenesin was tested to evaluate the effect of on pregnancy and in utero development of the rat. Doses of 0 (Control), 10, 50 and 100 mg/kg were administered to groups of twenty-five females, by oral gavage once per day, from Days 6 to 15 post coitum inclusive. For all dosage there is no evidence of maternal toxicity and no adverse effects on embryofoetal survival, growth and development in utero were recorded. The NOEL for Chlorphenesin in developing foetus was considered 100 mg/kg bw/day.
Justification for classification or non-classification
Chlorphenesin is not classified for reproductive toxicity according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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