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Diss Factsheets
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EC number: 208-293-9 | CAS number: 520-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study reported in 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- (only basic data given)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted Feb 1987
- Deviations:
- yes
- Remarks:
- (only basic data given)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- EC Number:
- 208-293-9
- EC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Cas Number:
- 520-45-6
- Molecular formula:
- C8H8O4
- IUPAC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Dehydroacetic acid
Test animals
- Species:
- rat
- Strain:
- other: albino
- Remarks:
- 200-300 grams body weight
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 24 h
- Housing: 5 animals of the same sex per common cage
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 1000, 1600, 2000, 2500, 3200, 4000, 5000 and 6400 g/kg (males)
1000, 1250, 1600, 2000, 2500, 3200, 4000, 5000 and 6400 g/kg (females) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 480 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 620 mg/kg bw
- Based on:
- test mat.
- Mortality:
- For details refer to Table 1 under "any other information on results"
- Clinical signs:
- other: All dose goups: lethargy 2000 mg/kg bw or more: gradual loss of motor control on the second day, magnified loss of motor control in further study progress, weight loss and debilitated survivors 5000 mg/kg or more: lack of motor control, hyperactive respo
Any other information on results incl. tables
Table 1: Acute oral toxicity
Dose | Mortality | Clinical signs |
[mg/kg bw] | ||
N* | N* | |
Males | ||
1000 | 0/5 | 5/5 |
1600 | 2/5 | 5/5 |
2000 | 4/5 | 5/5 |
2500 | 5/5 | 5/5 |
3200 | 5/5 | 5/5 |
4000 | 5/5 | 5/5 |
5000 | 5/5 | 5/5 |
6400 | 5/5 | 5/5 |
Females | ||
1000 | 0/5 | 5/5 |
1250 | 1/5 | 5/5 |
1600 | 3/5 | 5/5 |
2000 | 5/5 | 5/5 |
2500 | 5/5 | 5/5 |
3200 | 5/5 | 5/5 |
4000 | 5/5 | 5/5 |
5000 | 5/5 | 5/5 |
6400 | 5/5 | 5/5 |
*N = Number of animals
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 values determined were 1620 mg/kg bw for the males and 1480 mg/kg bw for the females.
- Executive summary:
An acute oral toxicity study was conducted in male and female rats. Dosages in the range 1000 to 6400 mg/kg bw were tested. The LD50 values determined were 1620 mg/kg bw for the males and 1480 mg/kg bw for the females. Clinical signs noted included: lethargy, lack of motor control, hyperactive responses, convulsions and hemorrhaging from the nose and mouth.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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