Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
The lowest reliable short-term toxicity to birds (Coturnix coturnix japonica) which is reported by Hussein A, Cantor A and Johnson T, 1988, after a 28 days exposure to aluminium sulphate was 5000 mg/kg food (EC50). One of the 28d NOAEC was 1000 mg/kg diet.
The NOELs can be converted to NOECs with the following two formulae:
NOECbird=NOAELbird.CONVbird
Conversion factors from NOAEL to NOEC for bird species Coturnix coturnix japonica is (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECbird=125 x 8=1000 mg/kg/diet
EC50=5 x 1000 =5000 mg/kg food
This information will be take into account for birds toxicity for the derivation of PNEC.
The lowest reliable long-term toxicity to birds (White leghorn laying ) which is reported by Wisser LA 1990,, after a 17 wk exposure to aluminium sulphate was 1500 mg/kg diet (NOAEC). One of the 17 wk NOAEC was 1500 mg/kg food.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC. TheNOELs can be converted to NOECs with the following two formulae: NOECbird=NOAELbird.CONVbird
Conversion factors from NOAEL to NOEC for bird species White leghorn laying hens is (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
NOECbird=187.5 x 8=1500 mg/kg/diet
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 5 000 mg/kg food
- Long-term EC10, LC10 or NOEC for birds:
- 1 500 mg/kg food
Additional information
Under the conditions of the study of Hussein A, Cantor A and Johnson T, 1988, aluminium sulphate induced No significantly decreased egg production, temporarily reduced eggshell-breaking strength and food consumption in Coturnix coturnix japonica below 5000 mg/kg food (EC50). One of the 28d NOEC was 1000 mg/kg diet.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
The NOELs can be converted to NOECs with the following two formulae:
NOECbird=NOAELbird.CONVbird
Conversion factors from NOAEL to NOEC for bird species Coturnix coturnix japonica is 8
(bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECbird=125 x 8=1000 mg/kg/diet
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC. TheNOELs can be converted to NOECs with the following two formulae: NOECbird=NOAELbird.CONVbird
Conversion factors from NOAEL to NOEC for bird species White leghorn laying hens is (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
NOECbird=187.5 x 8=1500 mg/kg/diet
Hussein et al. (1988) fed Japanese quail ( Coturnix coturnix japonica) on diets containing 0.05, 0.1, 0.15 and 0.3% aluminium (as aluminium sulfate) for 4 weeks. Egg production was significantly decreased at 0.1% and body weight gain at 0.15%. Feed intake was significantly depressed temporarily at 0.1 and 0.15% and permanently at 0.3%. Eggshell breaking strength was temporarily reduced (after 1 week only) at 0.1, 0.15 and 0.3%.
Hussein et al. (1989a) fed white leghorn laying hens on a diet containing 0.05, 0.1 or 0.15% aluminium (as aluminium sulfate) for 28 days. Feed intake, body weight, tibia breaking strength and plasmainorganic phosphorus were significantly reduced at 0.15%. Egg production was only significantly depressed after 21 days at 0.15%. Eggshell breaking strength was unaffected by the treatment. In asecond experiment hens were exposed to diets containing up to 0.3% aluminium for 42 days. Feeding 0.3% aluminium significantly decreased plasma inorganic phosphorus in samples collected immediately following oviposition (10 to 42 days). Plasma calcium, tibia weight and tibia breaking strength were unaffected. Egg production and feed intake weresignificantly reduced during days 1 to 21 but not during days 22 to42. The effects of 0.3% aluminium on the egg production and shellquality of laying hens are similar to those obtained with conventional force-moulting procedures using feed restriction (Hussein et al., 1989b).
Carrière et al. (1986) fed ring doves ( Streptopelia risoria) on a diet containing 0.1% aluminium sulfate with reduced calcium and phosphorus levels (0.9% Ca; 0.5% P) for a period of 4 months. There were no significant effects on egg production, fertility, hatchability, growth or final weight of chicks. Egg permeability was initially decreased but subsequently recovered to normal levels. The diet had no effect on plasma calcium, phosphorus or magnesium. There was no effect on weight or growth rate in juvenile doves fed diets containing 500, 1000 or 1500 mg/kg aluminium sulfate from day 21 to day 63.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.