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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Immunotoxicity
Administrative data
Description of key information
Orale exposure:
After three months treatment with Al2(SO4)3 in a dose of 300 mg/kg bw., hemoglobin and hematocrit levels of Al and Al+Vit E groups were significantly decreased compared to the control. Reductions in serum haemoglobin (14%) and haematocrit (13%) were described. There was an increase in the levels of liver iron (59%) and ferritin with Al, but Vit E had no effect on the changes of all blood and liver parameters caused by Al. From the results presented in this report, a Lowest Observed Adverse Effect Level (LOAEL) for Aluminium sulfate of 300 mg/kg/day was established, based on significantly decreased hemoglobin and hematocrit levels of Al .
Inhalation exposure:
Several animal studies have found histological alterations in the lymphoreticular system, in particular granulomas in the hilar lymph nodes; these effects are secondary to the pulmonary effects (Steinhagen et al. 1978; Thomson et al. 1986) and resulted from the removal of aluminum from the lungs by alveolar macrophages.
Dermal exposure:
No studies were located regarding immunological/lymphoreticular effects in animals after dermal exposure to various forms of aluminum.
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 300 mg/kg bw/day
Effect on immunotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 3.8 mg/m³
Effect on immunotoxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 7.5 mg/kg bw/day
Additional information
Orale exposure:
After three months treatment with Al2(SO4)3 in a dose of 300 mg/kg bw., hemoglobin and hematocrit levels of Al and Al+Vit E groups were significantly decreased compared to the control. Reductions in serum haemoglobin (14%) and haematocrit (13%) were described. There was an increase in the levels of liver iron (59%) and ferritin with Al, but Vit E had no effect on the changes of all blood and liver parameters caused by Al. From the results presented in this report, a Lowest Observed Adverse Effect Level (LOAEL) for Aluminium sulfate of 300 mg/kg/day was established, based on significantly decreased hemoglobin and hematocrit levels of Al .
Inhalation exposure:
Several animal studies have found histological alterations in the lymphoreticular system, in particular granulomas in the hilar lymph nodes; these effects are secondary to the pulmonary effects (Steinhagen etal. 1978; Thomson et al. 1986) and resulted from the removal of aluminum from the lungs by alveolar macrophages.
Dermal exposure:
No studies were located regarding immunological/lymphoreticular effects in animals after dermal exposure to various forms of aluminium.
For dermal exposure we taken that:
-the average weight of rats is 250g (200-300g),
-the dose is applied over an area which is approximately 10% of the total body surface=0.025 kg
corrected dermal LOAEL= oral LOAEL
300 mg/kg bw/dw 0.025 kg =
LOAELrat 7.5 mg/kg bw/day
Justification for classification or non-classification
There are conclusive but not suffcient data for the classification of substance Aluminium sulphate with regard to immunotoxicity.
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