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Diss Factsheets
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EC number: 203-481-7 | CAS number: 107-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment. Restrictions: purity of test substance not reported. Tested dose levels not reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and rabbits.
- Author:
- Munch JC
- Year:
- 1 972
- Bibliographic source:
- Industrial Medicine 41, 31-33.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl formate
- EC Number:
- 203-481-7
- EC Name:
- Methyl formate
- Cas Number:
- 107-31-3
- Molecular formula:
- C₂H₄O₂
- IUPAC Name:
- methyl formate
- Details on test material:
- TS-Freetext:
Homologous series of aliphatic alcohols and their alkyl
esters. Included methyl formate.
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral
- Vehicle:
- physiological saline
- Frequency of treatment:
- Single dose
- Details on study design:
- Observation period: 24 hours
Results and discussion
Any other information on results incl. tables
RS-Freetext:
(1) Narcotic and lethal doses of methyl formate:
ND50 = 27 millimols/kg bw.
LD50 = 27 millimols/kg bw.
27 millimols/kg bw correspond to 1620 mg/kg bw.
(2) Margin of safety: LD50/ND50=1.0
(3) The narcotic potential and the toxicity of the methyl
esters (formate, acetate, propionate, butyrate, isovalerate)
were much higher (by factors of 5-10) than the alcohol,
methanol. To a lower extent this effect was also seen with
ethanol, whereas in the C3-C5 series the potencies of the
alcohol and their esters were comparable to each other.
The narcotic potential and toxicity of the methyl esters
(only formate shown in the table below) was much higher
compared to the alcohol.
====================================================
ND50 LD50 [mmol/kg bw]
----------------------------------------------------
Methanol: 187.5 450
methyl formate: 27 27
====================================================
Applicant's summary and conclusion
- Conclusions:
- In rabbits, narcosis (ND50) and mortality (LD50) occurred
with methyl formate at the same oral dose (approx. 1620
mg/kg bw). Thus there was no margin of safety.
The narcotic potential and toxicity of the ester was much
higher compared to the alcohol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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