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Diss Factsheets
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EC number: 203-450-8 | CAS number: 106-99-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline, animal and human experimental study, predates implementation of GLP and/or development of study guidelines but otherwise acceptable for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the inhalation of 1,3-butadiene; with a comparison of its narcotic effect with benzol, toluol and styrene, and a note on the elimination of styrene by the human
- Author:
- Carpenter CP, Shaffer CB, Weir CS, Smyth HF
- Year:
- 1 944
- Bibliographic source:
- J Ind Hyg Toxicol 26; 69-78
Materials and methods
- Type of study / information:
- Evaluation of the effect on the psycho-motor response.
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Two male subjects inhaled 2000, 4000 or 8000 ppm 1,3-butadiene and their pulse rate, blood pressure and subjective symptoms were recorded. To evaluate the effect on the psycho-motor response, tapping rate and steadiness tests were performed before and during exposures.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-Butadiene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- 1,3-Butadiene
- Details on test material:
- Supplied by: Carbide and Carbon Chemicals Corporation
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Two male subjects inhaled 1,3-butadiene at concentrations of 2000 ppm for 7 hours, 4000 ppm for 6 hours and 8000 ppm for 8 hours. During exposure Pulse rate and blood pressure and subjective symptoms were recorded. Before and during exposures tapping rate and steadiness tests were performed to evaluate the effect on the psycho-motor response
- Exposure assessment:
- estimated
- Details on exposure:
- The subjects were exposed to 3 concentrations of 1,3-butadiene: 2000 ppm for 7 hours, 4000 ppm for 6 hours and 8000 ppm for 8 hours. The exposures were performed in a 4000 cu. ft. Room. Rapid and thorough mixing of the air was achieved by fans. Butadiene was bled directly from a cylinder. The vapour concentrations were estimated using an interferometer (concentration of butadiene calculated using the iodine pentoxide method) and controlled manually.
Results and discussion
- Results:
- SUBJECTIVE SYMPTOMS: At 2000 (4425 mg/m3) and 4000 ppm (8851 mgm3) 1,3-butadiene resulted in slight smarting of the eyes and difficulty in focusing on instrument scales. The odour was described as objectionable.
At 8000 ppm (17702 mg/m3) butadiene there were no subjective symptoms reported. It was proposed that this was due to slight anxiety/preoccupation with the control of this concentration (explosion risk). Following the first single exposure to butadiene, the subjects became much less aware of subjective symptoms when exposed subsequently to the same or a higher concentration.
STEADINESS TEST: Although unsteadiness was seen in both subjects at 4000 ppm, there was little or no effect noted at 8000 ppm or 2000 ppm.
The maximum time in contact (as % of day’s normal) was 266 and 136 for 4000 and 8000 ppm. At 2000 ppm the test was considered too brief to be reliable.
Any other information on results incl. tables
OTHER RESULTS:
BLOOD PRESSURE / PULSE RATE: Results were too variable to be of any significance.
TAPPING TEST: Minimum tapping rate in any 6 seconds (as % of day’s normal) was 100 at 8000 ppm with a maximum co-efficient of variation of 0.087. At 2000 and 4000 ppm the tests were too brief to be reliable and therefore the results were inconclusive.Applicant's summary and conclusion
- Conclusions:
- Two human volunteers inhaled 1,3-butadiene at concentrations up to 8000 ppm (17701 mg/m3). No immediate adverse effects were apparent at concentrations of 2000 and 4000 ppm (4425 and 8851 mg/m3) although the subjects stated that the odour was objectionable and smarting of the eyes was recorded.
- Executive summary:
1,3-butadiene was judged to be innocuous at the concentrations inhaled. At concentrations of 2000 and 4000 ppm (4425 and 8851 mg/m3) odour was considered to be objectionable. The authors stated that provided that the lower explosive limit is not exceeded, it is unlikely that the health of anyone inhaling its vapours will be impaired.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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