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EC number: 203-439-8 | CAS number: 106-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results. Study does not meet guideline requirements for minimum number of animals/dose level. .
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The dermal LD50 was examined using epichlorohydrin, neat, or diluted with propylene chloride with rabbits. Animals were observed until they died or regained pre-treatment weight.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2,3-epoxypropane
- EC Number:
- 203-439-8
- EC Name:
- 1-chloro-2,3-epoxypropane
- Cas Number:
- 106-89-8
- Molecular formula:
- C3H5ClO
- IUPAC Name:
- 2-(chloromethyl)oxirane
- Details on test material:
- >99% purity
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at Study Initiation: 2.43-3.50 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Dosed undiluted and as a 20% solution in propylene glycol
- Details on dermal exposure:
- Single dose
Area Covered: Unknown
Occlusion: Impervious cuff held in place with cloth bandage taped to hair
Removal of Test Material: Washing with soap and water 24 hours post-dosing
Maximum Volume Administered: 2.38 ml
Post-Dose Observation Period: 2 weeks - Duration of exposure:
- 24 hours
- Doses:
- Undiluted: 100, 200, 465, 795 mg/kg
20% solution in propylene glycol: 252, 500, 630 or 795 mg/kg - No. of animals per sex per dose:
- 2/sex/dose
- Control animals:
- no
- Details on study design:
- Approximately 24 hours prior to dosing, the hair was removed from the trunk of 2 laboratory white rabbits/dose level with electric clippers. The test material was applied at 100, 200, 465, or 795 mg/kg body weight under an impervious cuff held in place with a cloth bandage taped to the hair.
Following application the animals were returned to holding cages and allowed to eat and drink ad libitum. Following a 24-hour exposure period, the cuffs were removed and the skins washed with soap and water. The animals were observed during and after exposure and weighed at intervals up to two weeks post-application. The animals were then submitted for necropsy examination at death or at scheduled study termination. - Statistics:
- LD50 calculation method not specified
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 515 mg/kg bw
- Remarks on result:
- other: Undiluted
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 250 - 500 mg/kg bw
- Remarks on result:
- other: 20% solution in propylene glycol
- Mortality:
- Undiluted
# Dead/# Treated
Dose Male Female
(mg/kg)
100 0/2 0/2
200 0/2 0/2
465 1/2 0/2 Found dead 24 hours post-dosing
795 2/2 2/2 Found dead 24 hours post-dosing
20% solution in propylene glycol
# Dead/# Treated
Dose Male Female
(mg/kg)
252 0/2 0/2
500 2/2 2/2 Found dead 24-48 hours post-dosing
630 - 2/2 Found dead 24 hours post-dosing
795 - 2/2 Found dead 24 hours post-dosing - Clinical signs:
- other: Severe redness and swelling and slight necrosis were observed when the cuffs were removed after the 24-hour exposure to either test material.
- Gross pathology:
- no data
- Other findings:
- no additional information available
Any other information on results incl. tables
Two male and two female rabbits per dose level were exposed to undiluted epichlorohydrin or a 20% solution of epichlorohydrin in propylene glycol in acute percutaneous absorption tests. The LD50 for undiluted epichlorohydrin was 515 mg/kg and for the 20% solution in propylene glycol was between 250 and 500 mg/kg epichlorohydrin. Propylene glycol may enhance the toxicity of epichlorohydrin by this route as in the previous Dow Test.
Survivors dosed at 200 mg/kg and higher of either solution required 3 to 6 weeks to regain pre-treatment weight; animals dosed at 100 mg/kg required 2 to 3 weeks to regain pre-treatment weight. Severe redness and swelling and slight necrosis were observed when the cuffs were removed after the 24-hour exposure to either test material.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based on the results of the study LD50 for undiluted epichlorohydrin was 515 mg/kg and for the 20% solution in propylene glycol was between 250 and 500 mg/kg.
- Executive summary:
Two male and two female rabbits per dose level were exposed to undiluted epichlorohydrin or a 20% solution of epichlorohydrin in propylene glycol in acute percutaneous absorption tests. The LD50 for undiluted epichlorohydrin was 515 mg/kg and for the 20% solution in propylene glycol was between 250 and 500 mg/kg epichlorohydrin. Propylene glycol may enhance the toxicity of epichlorohydrin by this route as in the previous Dow Test.
Survivors dosed at 200 mg/kg and higher of either solution required 3 to 6 weeks to regain pre-treatment weight; animals dosed at 100 mg/kg required 2 to 3 weeks to regain pre-treatment weight. Severe redness and swelling and slight necrosis were observed when the cuffs were removed after the 24-hour exposure to either test material.
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