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Diss Factsheets
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EC number: 203-234-3 | CAS number: 104-76-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-09-01 until 1987-09-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexan-1-ol
- EC Number:
- 203-234-3
- EC Name:
- 2-ethylhexan-1-ol
- Cas Number:
- 104-76-7
- Molecular formula:
- C8H18O
- IUPAC Name:
- 2-ethylhexan-1-ol
- Details on test material:
- - Analytical purity: 99.5%
- Storage condition of test material: dry under inert gas
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Small Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. Karl Thomae GmbH, Biberach, Germany
- Weight at study initiation: 2.4 - 2.5 kg
- Housing: singly in stainless steel cages
- Diet: rabbit diet K4, Ssniff Spezialfutter GmbH, Soest, germany, ad libitum
- Water tap water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-
- Humidity (%): 60 +/-5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1987-09-01 To: 1987-09-15
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 µL - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm²
- Type of wrap if used: the application site was covered with a gauze patch (2.5 x 2.5 cm) followed by an impervious polyethylene foil. The patch was help in place by a flexible cotton wrap.
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: according to OECD 404 test guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hrs
- Score:
- 6.75
- Max. score:
- 8
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 h
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 h
- Score:
- 4
- Max. score:
- 4
Any other information on results incl. tables
Individual test results were as tabulated below. In addition, the skin was coloured in all animals at 24 hrs (yellow) and at 48 hrs (brown).
Animal No. |
1 h |
24 h |
48 h |
72 h |
6 d |
8 d |
10 d |
14 d |
|||||||||
ery |
ede |
ery |
ede |
ery |
ede |
ery |
ede |
ery |
ede |
ery |
ede |
ery |
ede |
ery |
ede |
||
1 |
2 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
scab |
Scab, des |
des, scar |
scar |
|||||
2 |
2 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
scab |
scab, rup |
scab, rup |
scab, des, scar |
|||||
3 |
2 |
3 |
3 |
4 |
3 |
4 |
4 |
4 |
scab, rup |
scab, rup |
scab, rup |
scab, des, scar |
Abbreviations:
Ery: erythema; ede: edema; figures: scores according to OECD 404
scab: scab formation; rup: ruptured; des: desquamation; scar: scar formation
No necrosis of the epidermis was reported.
A mean irritation index of 6.75 (maximum possible: 8) was calculated as the sum of all erythema and edema scores of all animals at 1, 24, 48, and 72 hours after patch removal, divided the number of animals (3) and time points (4).
The evaluation according to the directive 79/831/EEC gave means for each animal of 3.33 (erythema) and 4.0 (edema).
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 2-EH was highly irritating, as severe irreversible skin reactions were noted in all treated animals during 24 through 72 hours after patch removal which developed into formation of new skin and scars within 2 weeks after patch removal.
- Executive summary:
The skin irritation potential of 2 -EH, purity 99.5%, was tested in a valid non-GLP OECD 404 study using 3 rabbits. Severe erythema and edema was noted in all treated animals at 24 hours after treatment which persisted until 72 hours. The skin reactions caused irreversible changes and resulted in scab formation, desquamation, formation of new skin in all animals during days 6 through 14 after patch removal. Scars and peeling scabs were observed on day 14 in all animals. The observed effects including the late scarification are consistent with a strong irritant, but not a corrosive agent.
2 -EH was irritating according to EU legislation (Council directive 67/548/EEC and its amendment 79/831/EEC),
requiring the label Xi and R38 (Hüls AG, 1987). With respect to the CLP regulation (Regulation (EC) no 1272/2008) a classification in Skin Irritation category 2 seems justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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