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EC number: 297-907-9 | CAS number: 93763-87-2 Substance formed by processing of chiefly oxidic material with lead and zinc content in a rotating furnace. Consists primarily of Al2O3, CaO, Fe, FeO and SiO2 with other nonferrous compounds as well as carbon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study used as a key study in EU risk assessment of zinc metal
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Zinc
- EC Number:
- 231-175-3
- EC Name:
- Zinc
- Cas Number:
- 7440-66-6
- Molecular formula:
- Zn
- IUPAC Name:
- zinc
- Details on test material:
- metallic zinc dust (median particle diameter 4 micrometer
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- none
Test system
- Vehicle:
- not specified
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 mg of test substance
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- three male New Zealand White rabbits were treated by instillation of approximately 100 mg of the substance into the conjuctival sac of one eye. The other eye remained untreated and served as control. After 24 hours, both eyes of two animals were rinsed with water. The eyes were examined at 1, 24, 48 and 72 hours after instillation.
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- >= 0.7 - < 1
- Reversibility:
- fully reversible
- Remarks:
- in 72 h
- Irritant / corrosive response data:
- Slight irritation of the conjuctivae, which was seen as redness (grade 1-2; mean scores over 24-72 hours 1, 1 and 0.7) that had completely resolved at 72 hours in all animals. Chemosis (grade 1-2) was also observed in all animals at 1 hour only, while discharge (grade 1) was observed at 1 (two animals) and 24 hours (one animal).
- Other effects:
- no symptoms of systemic toxicity and no mortality occured. No iridial irritation and no corneal opacity or epithelial damage was observed in any of the animals.
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the eye irritation data, zinc dust is not irritating/corrosive to the eyes. Hence, according to EU criteria, metallic zinc does not have to be classified/labelled for irritating properties.
- Executive summary:
A well-performed eye irritation/corrosion studie, conducted according to Directive 92/69/EEC B.5 and OECD guideline 405, was carried out with metallic zinc dust (median particle diameter 4mm).
Three male New Zealand White rabbits were treated by instillation of approximately 100 mg of the substance into the conjuctival sac of one eye. The other eye remained untreated and served as control. After 24 hours, both eyes of two animals were rinsed with water. The eyes were examined at 1, 24, 48 and 72 hours after instillation.
No symptoms of systemic toxicity were observed and no mortality occurred. Also, no iridial irritation and no corneal opacity or epithelial damage was observed in any of the animals. Zinc dust caused slight irritation of the conjuctivae, which was seen as redness (grade 1-2; mean scores over 24-72 hours 1, 1 and 0.7) that had completely resolved at 72 hours in all animals. Chemosis (grade 1-2) was also observed in all animals at 1 hour only, while discharge (grade 1) was observed at 1 (two animals) and 24 hours (one animal).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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