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Diss Factsheets
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EC number: 201-209-1 | CAS number: 79-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Two non-GLP studies according to or similar to OECD guidelines 203 are available for the 2-nitropropane.
The key study determined a 96-hour LC50 for 2-nitropropane of >612.5 mg 2-nitropropane/L in the fathead minnow (Pimephales promelas). The supporting study determined a 48-hour LC50 for 2-nitropropane of 620 mg 2-nitropropane in the zebra fish (Brachydanio rerio (new name: Danio rerio)).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 612.5 mg/L
Additional information
Both studies lacked in specific detail but provided enough information to be considered acceptable with reservations. Neither study was conducted under good laboratory practice (GLP) principles. Both studies indicated that they had been conducted according to the OECD 203 Acute Fish toxicity guideline. Specifics on actual test conditions were lacking in both studies but implication is that the test conditions were according to the specified guideline requirements. Both reports indicated analytical confirmation of exposure concentrations were conducted and provided the analytical methodology but neither reported the results from these analyses. The exposure in the key study was not done under sealed vessel conditions so potential for volatilization of the test material existed. The exposure period for this test was 96 hours. The supporting study with zebra fish was conducted using covered vessels to minimize volatilization of the test material. The exposure period for this test was reported as 96 hours yet only 48 hour endpoints were presented. No explanation as to why 96 hour values were given. It is possible that since the test material was volatile and the exposure was static, thus not allowing for aeration of the test solutions, that dissolved oxygen dropped below minimum saturation (60%) during the last 48 hours of the test. With the fish loading and covering of vessels limiting air exchange this is a possibility. This may have left the data from 72 and 96 hours unusable. This is speculation but is a reasonable outcome based on experience.
Based on this information, the fathead minnow acute test is considered the key study for the short-term toxicity to fish endpoint. The LC50 >612.5 mg/L would result in a classification of Not Dangerous for this material based on fish toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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