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EC number: 401-680-5 | CAS number: 125304-04-3 TINUVIN 171; TINUVIN 571
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.05. - 13.06.2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- adopted 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- For the analysis of the actual test item concentrations the following samples were taken:
Just before test start:
- duplicate samples from the test medium (without daphnids)
- duplicate samples from the control (without daphnids)
After 48 hours (stability samples):
- duplicate samples from the test medium (without daphnids)
- duplicate samples from the control (without daphnids) - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
An undiluted filtrate of a supersaturated dispersion with the maximum concentration of dissolved test item was used as the only test concentration.
- Controls: test water without test item - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Clone 5
- Source: bred in the laboratories of RCC
- Age at study initiation: 6-24 hrs
- Method of breeding: in reconstituted water of the quality identical to the water quality used in the tests (regarding pH, main ions and total hardness) and under temperature and light conditions identical to those of the tests
- Feeding during test: no
ACCLIMATION
- Acclimation period: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 2.5 mmol/L (=250.0 mg/L) as CaCO3
- Test temperature:
- 20 °C
- pH:
- between 7.9 and 8.0 during test
- Dissolved oxygen:
- between 8.2 mg/L and 8.4 mg/L during test
- Nominal and measured concentrations:
- nominal: 100 mg/L (undiluted filtrate, loading rate)
measured: < 0.005 mg/L (calculated as the average over all measurements in the undiluted filtrate during the test period). - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beaker
- Type: beakers covered with glass plates
- Aeration: no
- No. of organisms per vessel: 20
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: < 1 Daphnia/ 2 mL test solution
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted test water: analytical grade salts were dissolved in purified water.
- Culture medium different from test medium: no
- Intervals of water quality measurement:
At the start and at the end of the test, the pH-values, the oxygen concentrations and the water temperature were determined In the single test concentration and the control. The appearance of the test medium was recorded at the start of the test and after 24 and 48 hours.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16-hour light to 8-hour darkness photoperiod with a 30 minute transition period
- Light intensity: between 550 and 685 Lux
EFFECT PARAMETERS MEASURED:
The immobility of the daphnids was determined by visual control after 24 and 48 hours of exposure. Those organisms not able to swim within 15 seconds after gentle agitation of the test beaker were considered to be immobile. The EC50 and the EC100 could not be calculated due to the absence of a toxic effect of the test item in this test at the tested concentrations. The NOEC, EC0 were determined directly from the raw data.
TEST CONCENTRATIONS
- Range finding study
The test concentrations were based on the results of a range-finding test and on results of a pre-experiment to the solubility of the test item (without GLP). - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.005 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.005 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Observations on body length and weight: no data
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no - Results with reference substance (positive control):
- For evaluation of the quality of the Daphnia magna clone and of experimental conditions, potassium dichromate is tested as a positive control at least once a year to demonstrate satisfactory test conditions. The results with the reference substance are not reported.
- Reported statistics and error estimates:
- Not performed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 19. - 20.12.1985
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, none GLP. In deviation from the current OECD guideline, the test duration was 24 hrs and not 48 hrs. Furthermore, high concentrations of an emulsifier were used in the preparation of the test medium.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 1984
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
- Nominal and measured concentrations:
- Nominal: 1.8; 3.2; 5.8; 10; 18; 32; 58 mg/L
Measured: 1; 1.7; 2.9; 7.1; 19.5; 22.3; 35.1 mg/L - Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 3.0 - 6.7 mg/L
Referenceopen allclose all
Description of key information
There is a high probability that the product is not acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Two studies on the toxicity to aquatic invertebrates are available. One of these studies (Ciba-Geigy 1986) is not regarded as valid due to the shortened exposure time of only 24 h and the use of high concentrations of emulsifier.
The valid study (RCC 2002) was conducted according to test guideline 92/69/EWG, C.2 (equivalent to OECD 202) under consideration of the OECD guidance document on aquatic toxicity testing of difficult substances (2000). This study did not reveal any toxicity in the range of water solubility. The 48-hour NOEC and the 48-hour EC0 of the test item to Daphnia magna were determined at a nominal concentration of 100 mg/L. The 48 -hour EC50 and the 48-hour EC100 were determined to be greater than 100 mg/L nominal concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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