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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 222-583-2 | CAS number: 3542-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Study period:
- 2006, 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline evaluation, medical standard procedure
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
- Reference Type:
- publication
- Title:
- Acute toxic effects of dioctyltin on immune system of rats
- Author:
- Kishi et al.
- Year:
- 2 006
- Bibliographic source:
- Environmental and Pharmacology 22 (2006) 240-247
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 431
- Deviations:
- not applicable
- Principles of method if other than guideline:
- see free text
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dioctyltin dichloride
- IUPAC Name:
- Dioctyltin dichloride
- Test material form:
- other: see free text
- Details on test material:
- -
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: see free text
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: see free text
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: see free text
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- see free text
- Frequency of treatment:
- see free text
- Duration of test:
- see free text
- No. of animals per sex per dose:
- see free text
- Control animals:
- other: see free text
Results and discussion
Effect levels
- Dose descriptor:
- other: see free text
- Sex:
- male/female
- Basis for effect level:
- other: see free text
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Applicant's summary and conclusion
- Conclusions:
- Tonk and Menke dedermined no adverse effect for reproduction and develomental in rat caused by Dioctyltin dichloride. The adverse effect in immune system is considered an acute effect, this is shown by Kishi. The adverse effect is completly reversible withhin a recovery time.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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