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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-394-3 | CAS number: 1782069-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Limitations in the reporting of experimental details and results
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Published study from a peer-reviewed journal.
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- Five experimental concentrations between 0.1 and 1000 μg/L.
- Details on test conditions:
- After 48 h, motile and immobilized Daphnia magna were counted.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.56 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 48-hour EC50 for Daphnia magna was 0.56 mg/L.
- Executive summary:
The test item was assessed in a 48-hour acute study with Daphnia magna. The study reports that OECD guideline 202 was followed, however limited methodological details are reported. Five test concentrations were used, between 0.1 and 1000 μg/L. The 48-hour EC50 for Daphnia magna was 0.56 mg/L. The study is assigned a Klimisch score of 2 (reliable with restrictions) as although it followed a standard test guideline the paper reports limited details on experimental design and results.
Reference
Description of key information
Based on nominal concentrations, the 48h EC50 for Daphnia magna was 0.56 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.56 mg/L
Additional information
The effects of the test item were determined in an acute immobilisation test with Daphnia magna, according to OECD 202 guideline (2011). The study was conducted under static conditions over a period of 48 hours with five nominal concentrations of the test item (0.4, 0.8, 1.6, 3.2, 6.4 mg/L). Twenty daphnids were exposed per treatment group (four replicates, each containing five daphnids). There was no analytical verification of the test item concentrations (although chemical analysis was undertaken for a chronic daphnid study conducted and reported in the same publication). Based on nominal concentrations, the 48h EC50 for Daphnia magna was 0.8 mg/L (95% confidence intervals: 0.72 - 0.88 mg/L).
In a second study (key study), the test item was assessed in a 48-hour acute study with Daphnia magna (2010). The study reports that OECD guideline 202 was followed, however limited methodological details are reported. Five test concentrations were used, between 0.1 and 1000 μg/L. The 48-hour EC50 for Daphnia magna was 0.56 mg/L. The study is assigned a Klimisch score of 2 (reliable with restrictions) as although it followed a standard test guideline the paper reports limited details.
As the results from both studies are similar, the study with the more sensitive result (EC50 = 0.56 mg/L) is taken as the key value for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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