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Diss Factsheets
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EC number: 701-394-3 | CAS number: 1782069-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: The hydrolysis of the test item was determined in lake water over 28 days using sterilised test vessels.
- Short description of test conditions: Test vessels were incubated in the dark at 25 ± 1 °C. Test solutions were shaken on a rotary shaker at 30 rpm. Flasks were covered with breathable membranes.
- Parameters analysed / observed: Test item concentration was determined by HPLC-DAD. - GLP compliance:
- no
- Remarks:
- Published study from a peer-reviewed journal.
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0, 1, 2 6, 10, 15, 21, and 28 days
- Sampling method: 1 mL of water sample was withdrawn from each flask for the analysis.
- Sample storage conditions before analysis: Prepared samples were transferred to 2-mL amber glass vials and stored at -20 C until analysis. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 250-mL Erlenmeyer flask
- Sterilisation method: Autoclave at 120 °C for 30 min
- Lighting: Constant darkness
- Measures taken to avoid photolytic effects: Flasks were wrapped with aluminium foil.
- Measures to exclude oxygen: None, flasks were covered with breathable membranes.
- Details of traps for volatile, if any: None
- If no traps were used, is the test system closed/open: Open
TEST MEDIUM
- Volume used/treatment: 100 mL
- Kind and purity of water: Lake water sample, filtered through a paper filter (pore size 3 to 5 μm).
OTHER TEST CONDITIONS
- Dissolved organic carbon: 5.66 mg/L - Duration:
- 28 d
- pH:
- 7.6
- Temp.:
- 25 °C
- Initial conc. measured:
- 2 mg/L
- Number of replicates:
- 3
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- Key result
- Remarks on result:
- not determinable
- Remarks:
- No degradation observed
- Details on results:
- Degradation of the test item in sterilised lake water in the dark showed no significant (ANOVA, p <0.3) decrease in concentrations over 28 days, indicating that hydrolysis is of minor important for the removal of the test item in lake water.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- There was no significant decrease in test item concentration in sterilised lake water in the dark over 28 days, indicating that hydrolysis is of minor importance for the removal of the test item in lake water.
- Executive summary:
The hydrolysis of the test item was determined in a 28 day test. A nominal concentration of 2 mg/L test item was added to lake water and incubated in the dark at 25 ± 1 °C. Flasks were covered with breathable membranes and samples were taken at 0, 1, 2, 6, 10, 15, 21, and 28 days for analysis of the test item by HPLC-DAD. There was no significant decrease in test item concentration in sterilised lake water in the dark over 28 days, indicating that hydrolysis is of minor importance for the removal of the test item in lake water. This study is considered to be reliable with restrictions (Klimisch 2) as the test design was adequate, however there are limitations in the reporting of results.
Reference
Description of key information
No significant decrease in test item concentration by hydrolysis in water was detected over 28 days.
Key value for chemical safety assessment
Additional information
A hydrolysis study was performed in which a nominal concentration of 2 mg/L test item was added to lake water and incubated in the dark at 25 ± 1°C for 28 days (2015). Flasks were covered with breathable membranes and samples were taken at 0, 1, 2, 6, 10, 15, 21, and 28 days for analysis of the test item by HPLC-DAD. There was no significant decrease in test item concentration in sterilised lake water in the dark over 28 days, indicating that hydrolysis is of minor importance for the removal of the test item in lake water. This study is considered to be reliable with restrictions (Klimisch 2) as the test design was adequate, however there are limitations in the reporting of results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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