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Diss Factsheets
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EC number: 700-403-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
This substance was tested for acute oral and inhalation toxicity. The aqueous dispersion was tested (approx. 20% solids and 80% water) was administered directly without correction for active ingredient in an acute oral up/down study in rats. In this study, the material was not toxic and the LD 50 was determined to be > 5000 mg aqueous dispersion/kg or > 1000 mg a. i. /kg of the substance. In another acute oral up/down LD50 study, female mice were administered the test substance formulation and the LD50 was determined to be > 5000 mg aqueous dispersion/kg. A correction for active solids was made and an additional dose was administered with no mortality resulting from > 2000 mg a. i. /kg. Due to animal welfare considerations, no further oral administrations at higher corrections were made and the LD50 can be estimated to be > 2000 mg a. i. /kg. An acute inhalation toxicity study was conducted on the substance according to OECD 436, acute toxic class method. In this study, 0/3 male and 1/3 female rats died at a measured aerosol concentration of 126 mg total solids/m3, and 2/3 male and 2/3 female rats died at a measured aerosol concentration of 263 mg total solids/m3. It was concluded that the 4-hour LC50 of the substance in rats was between 126 and 263 mg total solids/m3 as measured aerosol (MMAD ~2.3 μm), indicating the material may be toxic with inhalation of respirable particulate; the vapor is not expected to be toxic.
Justification for classification or non-classification
This substance is not classified for acute oral toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, as the LD50 was estimated to be >2000 mg a.i./kg in mice.
No acute lethality study was conducted via the dermal route of exposure; therefore, this endpoint cannot be classified.
An inhalation LC50 determination according to the acute toxicity class method has been conducted that indicates the 4-hour LC50 is between 126 and 263 mg total solids/m3 as measured, respirable aerosol. Accordingly, the substance is classified at Cat 2 (H330: Fatal if inhaled) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. Additionally, although no histopathological evaluation was conducted on animals exposed to the test substance via inhalation, several structurally-related, multi-constituent fluorinated phosphate esters (see Chapter13 in IUCLID for additional information) have shown clinical signs of respiratory distress, gross pathological changes and adverse histopathological effects in the lungs and/or larynx following acute inhalation at measured aerosol concentrations between 8 and 98 mg/m3. The clinical signs and gross/anatomic pathology observed among these related fluorinated phosphate esters are consistent with local epithelial injury, however, none of these related substances are corrosive or exhibit remarkable irritation to skin or mucous membranes in guideline studies. Given the potential for respiratory tract injury for related fluorinated phosphate esters at relatively low exposure concentrations, the test substance is classified as STOT Single Exp. 1 (H370: Causes damage to organs; lungs and larynx via inhalation) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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