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Diss Factsheets
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EC number: 308-516-0 | CAS number: 98072-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
No information on animal testing of “Slimes and Sludges, precious metal refining" is available. “Slimes and Sludges, precious metal refining" 3 contains ≥ 1 % nickel chloride (specific concentration limits of nickel chloride; see "justification for classification and non-classification" below). Hence, “Slimes and Sludges, precious metal refining" 3 meets classification criteria for STOT RE 1 via the inhalation route.
“Slimes and Sludges, precious metal refining" 4 contains ≥ 1 % nickel chloride and ≥ 0.3 % lead and lead compounds relevant for C&L of grade 4. For all constituents there are specific concentration limits (SCLs) given for STOT RE classification (see discussion). Based on the SCLs and the specific rules for mixtures of Regulation (EC) 1272/2008 “Slimes and Sludges, precious metal refining" 4 requires classification as STOT RE 1.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Substance specific information for the UVCB substance "Slimes and Sludges, precious metal refining"is not available for the endpoint "Repeated Dose Toxicity". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as a specific target organ toxicant that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.9.3.4 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.
In total, four different grades of "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Slimes and Sludges, precious metal refining"two C&L entries for specific target organs toxicity (i.e., no C&L and STOT RE 1) were generated. Each group is described in a separate endpoint study record and endpoint summary.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
i.e., lead and lead compounds. It is noted that lead and lead compounds are only considered for Slimes and Sludges, precious metal refining grade 4- The lead and lead compound content in Slimes and Sludges, precious metal refining grade 3 is below the cut-off value for C&L of mixtures in accordance with Regulation (EC) 1272/2008.
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
i.e., nickel chloride
Justification for classification or non-classification
Classification driver for STOT RE 1 are:
(i) Lead and lead compounds - oral (grade 4)
According to the self-classification of lead compounds thespecific concentration limits (SCL) for STOT RE classification are as follows:
STOT RE 1; H372: C ≥ 0.5%
STOT RE 2; H373: 0.05% ≤ C < 0.5%
(ii) Nickel dichloride – inhalation (grade 3 & 4)
According to the self-classification of nickel chloride the specific concentration limits (SCL) for STOT RE classification (inhalation) are as follows:
STOT RE 1; H372: C ≥ 1 %
STOT RE 2; H373: 1 % ≤ C < 7 %
Classification of UVCB substances as being toxic to specific target organs after repeated dose application is based on the presence of a constituent ≥ 1 % classified as STOT-RE 1 and of a constituent ≥ 10 % classified as STOT-RE 2, respectively. However, for lead compounds and nickel dichloride there are specific concentration limits given for STOT RE classification assigned by the lead/nickel industry. According to Regulation (EC) 1272/2008 “specific concentration limits” should take precedence over any other concentration limits for the purpose of classification.
The classification driver for STOT RE classification of “Slimes and Sludges, precious metal refining” 3 is nickel dichloride in concentration relevant for C&L as STOT RE 1. The classification drivers for STOT RE classification of “Slimes and Sludges, precious metal refining” 4 are nickel dichloride and lead and lead compounds in concentration relevant for C&L as STOT RE 1.
Hence, “Slimes and Sludges, precious metal refining” 3&4 meets classification criteria as STOT RE 1 and requires labelling with H372 (causes damage to organs).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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