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Diss Factsheets
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EC number: 257-473-3 | CAS number: 51851-37-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-04-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
- Test temperature:
- 18-22°C were hold by cooling the water in the incubation vessel with ice.
At the beginning of incubation: 18-19°C
During the determination of oxygen content: 18.8-19.9°C - Dissolved oxygen:
- Control 1: 38.93 mg O2/l*h
Control 2: 39.20 mg O2/l*h
The difference between control 1 and 2 does not exceed 15% (i.e. 0.7%) - Reference substance (positive control):
- yes
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 300 mg/L
- Details on results:
- In the tested concentration range of 67, 133, 267, 534, and 1334 mg/l there was no inhibitory dose-effect-level
- Results with reference substance (positive control):
- A positive control test with 3, 5-dichlorophenol yielded an EC50 of 7.3 mg/l, which is within the accepted range of 5 to 30 mg/l required by the guideline for a valid study.
- Validity criteria fulfilled:
- yes
- Conclusions:
- An activated sludge respiration inhibition 3hr EC50 value of >1300 mg/l was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. This indicates that the test substance was not toxic to waste water (activated sludge) bacteria at a nominal concentration of 1300 mg/l.
Reference
Description of key information
Toxicity to microorganisms: Activated sludge respiration inhibition 3-hour EC50 > 1300 mg/l (highest concentration tested) (OECD 209).
Key value for chemical safety assessment
Additional information
An activated sludge respiration inhibition 3-hour EC50 value of >1300 mg/L was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. This indicates that the test substance, [2-(perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7, EC 257-473-3), was not toxic to waste water (activated sludge) bacteria at a nominal concentration of 1300 mg/l.
[2-(Perfluorohexyl)ethyl]triethoxysilane in contact with water, hydrolyses moderately to form [2-(perfluorohexyl)ethyl]silanetriol and ethanol. Refer to IUCLID Section 6.1 and Section 7.1 of the CSR for discussion of the surface active properties of the parent substance, silanol hydrolysis product and condensation products and further discussion of the hydrolysis rates of the parent substance.
Ethanol does not have adverse effects on microorganisms (OECD, 2004).
Reference:
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 19-22 October 2004, Ethanol, CAS 64-17-5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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