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EC number: 257-473-3 | CAS number: 51851-37-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2005-04-26 to 2004-05-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Kurume Laboratory of Chemicals Evaluation and Research Institute, Japan
- Date of receipt: 2005-04-14
- Culturing: Once a day, about one third of the medium was removed and an equal volume of 0.1% synthetic waste water was added
- Mixed Liquor Suspended Solid (MLSS): 4700 mg/l - Duration of test (contact time):
- ca. 28 - ca. 29 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- The test substance was exposed to activated sludge in an automatic BOD meter. The biological oxygen demand (BOD) was measured for 28 days. After the completion of BOD measurement, dissolved organic carbon (DOC) and residential test substance were measured. Biodegradability of the test substance was assessed based on the results of these measurements.
- Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 7
- Sampling time:
- 28 d
- Details on results:
- The calculation of the degradation curve was performed with the help of a computer program contained in WordPerfect.
On day 28, the remaining dissolved CO2 was expelled by acidifying the samples. No further biological degradation occured since the microorganisms were killed by acidification. The degradation values obtained on day 29 (end of incubation) were therefore assigned to day 28.
The test substance achieved a degradation of 9% within 28 days (mean of two test substance samples). - Results with reference substance:
- The degradation of aniline based on BOD was 79% on day 14.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- 7% biodegradation in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1997-03-18 to 1997-04-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Version / remarks:
- Modified sturm test
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- The activate sludge was obtained from a communal sewage treatment plant. 20 ml was used to inoculate the test samples. The suspended solids content of the test samples was 29.7 mg/L and the dry solids content of the inoculate used was 4.4 g/L. The bacterial count of the inoculate was 122 x10E4 colony-forming units/ml
- Duration of test (contact time):
- 29 d
- Initial conc.:
- 45.8 mg/L
- Based on:
- test mat.
- Initial conc.:
- 45.5 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The test substance was added to the liquid medium that had been inoculated with activated sludge and aerated. The evolved carbon dioxide was bound in sodium hydroxide in the form of sodium carbonate. The degradation was followed for a test duration of 29 days, and the bound CO2 was checked by TOC analysis after 0,3,6,9,15,24,28 and 29 days.
- Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 9
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of two batches.
- Details on results:
- The calculation of the degradation curve was performed with the help of a computer program contained in WordPerfect.
On day 28, the remaining dissolved CO2 was expelled by acidifying the samples. No further biological degradation occured since the microorganisms were killed by acidification. The degradation values obtained on day 29 (end of incubation) were therefore assigned to day 28.
The test substance achieved a degradation of 9% within 28 days (mean of two test substance samples). - Results with reference substance:
- The control substance, sodium benzoate obtained a degradation of 92% within 28 days. The proportional degradation of the control substance reached the plateau for ready biodegradability within 14 days. Therefore, the test methodology was considered valid for assessment.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- 9% biodegradation in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Referenceopen allclose all
pH measured
After the completion of BOD measurement, the pH values of the test solutions was all 7.2 in the test suspensions 1, 2 and 3 and was similar to that on the initiation of BOD measurement (pH = 6.9)
Table 1: pH measurement
Bottle no |
Substance |
pH |
|
|
|
Day 0 |
Day 28 |
1 |
Aniline |
- |
8.0 |
2 |
- |
6.9 |
7.2 |
3 |
Dynasylan F8261 |
- |
7.2 |
4 |
Dynasylan F8261 |
- |
7.2 |
5 |
Dynasylan F8261 |
- |
7.2 |
6 |
Dynasylan F8261 |
8.0 |
8.1 |
BOD Measurement
On day 28, while ThOD was 28.2 mg, BOD was 1.9, 0.6 and 3.7 mg (corrected values with BOD of the inoculum blank) in the test suspension 1, 2 and 3 respectively and 2.5 mg in the abiotic control. Degradability based on BOD was 7, 2, 13%, the average was 7% and the difference of maximum and minimum was 11% and below 20%.
Table 2: BOD measurement
Bottle No |
Substance |
ThOD (mg) |
Day 7 |
Day 14 |
Day 21 |
Day 28 |
||||||||
|
BOD (mg) |
∆BOD (mg) |
Degradability (%) |
BOD (mg) |
∆BOD (mg) |
Degradability (%) |
BOD (mg) |
∆BOD (mg) |
Degradability (%) |
BOD (mg) |
∆BOD (mg) |
Degradability (%) |
||
1 |
Aniline |
90.2 |
63.3 |
59.5 |
66 |
75.4 |
70.9 |
79 |
76.6 |
71.5 |
79 |
77.5 |
71.3 |
79 |
2 |
- |
- |
3.8 |
- |
- |
4.5 |
- |
- |
5.1 |
- |
- |
6.2 |
- |
- |
3 |
Dynasylan F8261 |
28.2 |
5.2 |
1.4 |
5 |
6.1 |
1.6 |
6 |
6.8 |
1.7 |
6 |
8.1 |
1.9 |
7 |
4 |
Dynasylan F8261 |
28.2 |
4.4 |
0.6 |
2 |
5.0 |
0.5 |
2 |
5.6 |
0.5 |
2 |
6.8 |
0.6 |
2 |
5 |
Dynasylan F8261 |
28.2 |
5.8 |
2.0 |
7 |
6.5 |
2.0 |
7 |
8.0 |
2.9 |
10 |
9.9 |
3.7 |
13 |
6 |
Dynasylan F8261 |
28.2 |
2.5 |
- |
- |
2.5 |
- |
- |
2.5 |
- |
- |
2.5 |
- |
- |
|
Average (%) (bottle no. 3, 4, 5) |
7 |
||||||||||||
Standard deviation (%)(bottle no. 3, 4, 5) |
5.5 |
|||||||||||||
Difference between maximum and minimum value (%)(bottle no. 3, 4, 5) |
11 |
∆BOD = [BOD of bottle no 3, 4, 5] – [BOD of bottle no 2]
DOC measurement
On day 28, while the theoretical organic carbon (TOC) concentration was 9.9 mg, DOC was 0(-0.1), 0(-0.1) and 0 mg (corrected values with DOC of the inoculum blank) in the test suspension 1, 2 and 3 respectively and 5.3 mg in the abiotic control. Where DOC was calculated to be negative, this value is shown in parenthesis.
Degradability based on DOC was not calculated because the guttiform test substance was precipitated and insoluble in test suspension.
Table 3: DOC measurement
Bottle No |
Test substance |
Test substance added (mg) |
Day 28 |
||||
|
|
|
TC (mg/l) |
IC (mg/l) |
DOC (mg/l) |
DOC (mg) |
∆DOC (mg) |
2 |
- |
- |
0.9 |
0.0 |
0.9 |
0.3 |
- |
3 |
Dynasylan F8261 |
9.9 |
0.6 |
0.0 |
0.6 |
0.2 |
0(-0.1)* |
4 |
Dynasylan F8261 |
9.9 |
0.7 |
0.0 |
0.7 |
0.02 |
0(-0.1)* |
5 |
Dynasylan F8261 |
9.9 |
0.9 |
0.0 |
0.9 |
0.3 |
0.0 |
6 |
Dynasylan F8261 |
9.9 |
17.5 |
0.0 |
17.5 |
5.3 |
- |
∆BOD = [BOD of bottle no 3, 4, 5] – [BOD of bottle no 2]
*where ∆DOC was calculated to be negative, this value in parenthesis
Measurement of residual test substance (table 4)
The correlation coefficient of the analytical curve concentration and peak area was 0.99971, this indicate good relationship.
On day 28, compared with the standard solution, no new peaks/chromatograms where found for the test suspensions. Average disappearance rates of the test substance was 8% and in the abiotic control, it was 99%.
Table 4: Residual test substance measurement
Bottle No |
Test substance |
Test substance added (mg) |
Day 28 |
|||
Test substance |
Disappearance (%) |
|||||
Measured value (mg/l) |
Correction value (mg/l)* |
mg |
||||
3 |
Dynasylan F8261 |
30.0 |
90.2 |
100.2 |
30.1 |
0 |
4 |
Dynasylan F8261 |
30.0 |
89.8 |
99.8 |
29.9 |
0 |
5 |
Dynasylan F8261 |
30.0 |
68.5 |
76.1 |
22.8 |
24 |
6 |
Dynasylan F8261 |
30.0 |
1.1 |
1.2 |
0.4 |
99 |
Average (%) (bottle no 3, 4, 5) |
8 |
|||||
Standard deviation (%) (bottle no 3, 4, 5) |
13.9 |
*measured values of the concentration of the test substance in the test solutions were corrected with the recovery rate
(measured value) x 100/96 = correction value
Table 1: TOC analysis for blank, control and test substance
mg TOC/L 0.05 M NaOH |
||||||
Time (days) |
Blank A |
Blank B |
Avg. of blank A and B |
Control |
Test substance A |
Test substance B |
30 min |
1.19 |
1.44 |
1.32 |
1.34 |
1.40 |
1.63 |
3 |
5.31 |
4.95 |
5.13 |
27.70 |
5.60 |
5.93 |
6 |
8.72 |
7.76 |
8.24 |
40.45 |
9.00 |
9.46 |
9 |
11.84 |
11.20 |
11.52 |
47.95 |
13.56 |
13.42 |
15 |
15.81 |
15.06 |
15.44 |
54.53 |
19.86 |
19.65 |
20 |
18.36 |
17.64 |
18.00 |
57.75 |
21.72 |
22.83 |
24 |
18.90 |
18.27 |
18.59 |
58.80 |
22.17 |
23.19 |
28 |
20.07 |
19.74 |
19.91 |
59.78 |
23.97 |
23.91 |
29 |
20.16 |
19.77 |
19.97 |
60.34 |
23.67 |
24.39 |
Table 2: Calculation of degradation for control substance
Theoretical CO2 production: 53.6 mg/l
Test duration |
TOC mg/l NaOH (0.05 M)
|
CO2 mg/l sample |
Degradation (%) |
||
|
Sodium benzoate |
Avg of blanks |
Difference/3 (3 L test vessel used) |
Correction for molecular weight of C and CO2 |
|
30 min |
1.34 |
1.32 |
0.01 |
0.04 |
0 |
3 |
27.70 |
5.13 |
7.52 |
27.60 |
51 |
6 |
40.45 |
8.24 |
10.74 |
39.42 |
74 |
9 |
47.95 |
11.52 |
12.14 |
44.55 |
83 |
15 |
54.53 |
15.44 |
13.03 |
47.82 |
89 |
20 |
57.75 |
18.00 |
13.25 |
48.63 |
91 |
24 |
58.80 |
18.59 |
13.40 |
49.18 |
92 |
28 |
59.78 |
19.91 |
13.29 |
48.77 |
91 |
29 after acidification |
60.34 |
19.97 |
13.46 |
49.40 |
92 |
Table 3: Calculation of degradation for sample A
Theoretical CO2 production: 55.4 mg/l
Test duration |
TOC mg/l NaOH |
CO2 mg/l sample |
Degradation (%) |
||
|
Test substance |
Avg of blanks |
Difference/3 (3 L test vessel used) |
Correction for molecular weight of C and CO2 |
|
30 min |
1.40 |
1.32 |
0.03 |
0.11 |
0 |
3 |
5.60 |
5.13 |
0.16 |
0.59 |
1 |
6 |
9.00 |
8.24 |
0.25 |
0.92 |
2 |
9 |
13.56 |
11.52 |
0.68 |
2.50 |
5 |
15 |
19.86 |
15.44 |
1.47 |
5.39 |
10 |
20 |
21.72 |
18.00 |
1.24 |
4.55 |
8 |
24 |
22.17 |
18.59 |
1.19 |
4.37 |
8 |
28 |
23.97 |
19.91 |
1.35 |
4.95 |
9 |
29 after acidification |
23.67 |
19.97 |
1.23 |
4.51 |
8 |
Table 4: Calculation of degradation for sample B
Theoretical CO2 production: 55.1 mg/l
Test duration |
TOC mg/l NaOH |
CO2mg/l sample |
Degradation (%) |
||
|
Test substance |
Avg of blanks |
Difference/3 (3 L test vessel used) |
Correction for molecular weight of C and CO2 |
|
30 min |
1.63 |
1.32 |
0.10 |
0.37 |
1 |
3 |
5.93 |
5.13 |
0.27 |
0.99 |
2 |
6 |
9.46 |
8.24 |
0.41 |
1.50 |
3 |
9 |
13.42 |
11.52 |
0.63 |
2.31 |
4 |
15 |
19.65 |
15.44 |
1.40 |
5.14 |
9 |
20 |
22.83 |
18.00 |
1.61 |
5.91 |
11 |
24 |
23.19 |
18.59 |
1.53 |
5.62 |
10 |
28 |
23.91 |
19.91 |
1.33 |
4.88 |
9 |
29 after acidification |
24.39 |
19.97 |
1.47 |
5.39 |
10 |
Table 5: Mean calculation of sample A and sample B
Determination of the mean degradation of the test substance (%)
Degradation after day |
Vessel 11 (%) |
Vessel 12 (%) |
Mean value of Vessel 11 and Vessel 12 (%) |
30 min |
0 |
1 |
1 |
3 |
1 |
2 |
2 |
6 |
2 |
3 |
3 |
9 |
5 |
4 |
5 |
15 |
10 |
9 |
10 |
20 |
8 |
11 |
10 |
24 |
8 |
10 |
9 |
28 |
9 |
9 |
9 |
29 after acidification |
8 |
10 |
9 |
Description of key information
Biodegradation in water (screening tests): 7% and 9% in 28 days (EU Method C.4-C, MITI test). The silanol hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol, is not expected to biodegrade to any significant extent.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
Two reliable ready biodegradation studies are available for the registration substance. In the first study (Diefenbach, 1997), ready biodegradation study was conducted for the registration substance in accordance with EU Method C.4 and in compliance with GLP. A biodegradation value of 9% in 28 days was obtained for the substance. Similarly, in the second study (Omura, 2005), a biodegradation value of 7% DOC removal in 28 days was determined for the substance using a relevant test method and in compliance with GLP. The results are considered to be reliable and are used as weight of evidence.
[2-(Perfluorohexyl)ethyl]triethoxysilane hydrolyses moderately rapidly to form [2-(perfluorohexyl)ethyl]silanetriol and ethanol. [2-(Perfluorohexyl)ethyl]silanetriol is not expected to biodegrade to any significant extent.
Ethanol is readily biodegradable (OECD, 2004).
The measured biodegradation of the registration substance is lower than expected based on hydrolysis within the time period of the biodegradation studies, followed by biodegradation of the ethanol hydrolysis product. A total degradation of approximately 43% is expected, due to degradation of ethanol. The lower measured biodegradation of the substance may be related to its low water solubility and the high loading rate in the study, limiting its hydrolysis.
Reference:
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 19-22 October 2004, Ethanol, CAS 64-17-5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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