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Diss Factsheets
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EC number: 218-747-8 | CAS number: 2224-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Studies conducted by the Japanese Ministry of the Environment based on based on OECD-GLP standard and OECD test guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Deviations:
- yes
- Remarks:
- (no details on method)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- High performance liquid chromatography (HPLC) on day 0, 7 and 14.
- Test organisms (species):
- Oryzias latipes
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- 24 ± 1 ºC
- Nominal and measured concentrations:
- 6.25, 12.5, 25.0, 50.0, 100.0 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 1.8 L
- Aeration: No
- Type of flow-through (e.g. peristaltic or proportional diluter): no data.
- No. of organisms: 10 animals per concentration.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light/ 8 hours dark
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.0 - Reference substance (positive control):
- not specified
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 14d-LC50 and 14d-NOEC of 2-butanone oxime in fish (Oryzias lapides) was determined to be >100 and 50 mg/L respectively.
- Executive summary:
A fish prolonged toxicity test was performed by the Japanese Ministry of the Environment according to OECD TG 204. The test duration was 14 days. The 14 d-LC50 and 14d-NOEC of test substance 2 -butanonen oxime in fish (Oryzias lapides) was determined to be >100 and 50 mg/L respectively.
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Butan-2-one O,O',O''-(vinylsilanetriyl)oxime undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding silanol. Silanetriol undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to butanone oxime and their values are comparable.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 119.94 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: (analogue substance)
- Basis for effect:
- mortality
- Remarks on result:
- other: (read-across from an analogue substance)
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 59.97 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: (analogue substance)
- Basis for effect:
- other: no data
- Remarks on result:
- other: (read-acros from an analogue substance)
- Details on results:
- Based on the experimental results obtained in the Fish, Prolonged Toxicity Testwith on the analogue substance butanone oxime (14d-LC50 >100 mg/L and 14d-NOEC = 50 mg/L ), the read-across approach was applied and the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from experimental results on analogue butanone oxime, the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.
- Executive summary:
A fish Prolonged Toxicity Test: 14-day Study was performed on analogue substance butanone oxime by the Japanese Ministry of the Environment according to OECD 204. The 14d-LC50 in fish (Oryzias lapides) was determined to be >100 mg/L and the 14d-NOEC was 50 mg/L. Based on these results, the read-across approach was applied and the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.
Referenceopen allclose all
Description of key information
Key study: Read-across from experimental data on analogue butanone oxime. The 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.94 and 59.97 mg/L respectively.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 59.97 mg/L
Additional information
Read-across approach from analogue butanone oxime:
Key study: Based on the read-across approach from experimental data on analogue butanone oxime (test method equivalent to OECD 204, 14d-LC50 in fish (Oryzias lapides) > 100 mg/L and 14d-NOEC = 50 mg/L), the read-across approach was applied and the 14d-LC50 and 14d-NOEC of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in fish (Oryzias lapides) was determined to be >119.34 and 59.97 mg/L respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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