Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-344-0 | CAS number: 793-24-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of N-(1,3-dimethylbutyl)-N'-phenylbenzene-1,4-diamine to invertebrates (Dapnia magna) was conducted under Flow-through immobilisation test according OECD Guideline 202. After 48 hours of exposure an EC50 of 0.23 mg/L (measured) is obtained (MITI, Ed. by CITI,
Ministry of International Trade & Industry Japan, 1999). A lower effect value is known from the secondary hydrolysis product p-hydroquinone which was used as a key value.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.13 mg/L
Additional information
Short-term tests have been performed with 6PPD as well as with other similar PPDs yielding EC50-values in the range of 0.2 to 1.7 mg/L. The result of the study performed with 4-HDPA (0.69 mg/L) is within this range.
N-(1,3-dimethylbutyl)-N'-phenylbenzene-1,4-diamine (6PPD) is hydrolytically unstable at pH 7 and 4-hydroxydiphenylamine (CAS 122-37-2) was identified as the most sensitive (secondary) hydrolysis product.
The lowest effect value in acute tests was found for p-Hydroquinone (0.13 mg/L) which is close to the values for the PPDs (0.2 to 1.9 mg/L) and 4-HDPA (0.69 mg/L).Although p-Hydroquinone is a secondary hydrolysis product of 6PPD, it was chosen as a source of key value as it shows the lowest effect concentrations of all PPDs and their degradation products and therefore represents the worst case.
For 4-HDPA and, N-Phenylbenzoquinone-imine calculated values are available. These calculated values should only be used only for a rough estimation due to the high uncertainty of the method. However they show a trend: The effect values of these three intermediate compounds to daphnids are at a higher level and there is no sign for a higher toxicity than found for the PPDs or any of their degradation products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.