Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-344-0 | CAS number: 793-24-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A QSAR for the original substance 6PPD yielded a bioconcentration factor of 568.7 was taken and justified as key value.
Measured BCFs of the two main hydrolysis products of 6PPD, 4-hydroxydiphenylamine and its oxidised form N-Phenylphenyl-p-benzoquinone monoimine, ranges from 3.3 - 49 and < 1.2 - 23, respectively. A further degradation product is 1,3-dimethylbutylamine. The BCF values range from 1.7 - 17. All three substances were investigated by the Chemicals Inspection & Testing Institute of Japan (CERI, 1995, National Institute of Technology and Evaluation 2002) according to OECD Guideline 305 C, using Cyprinus carpio as test organism.
Key value for chemical safety assessment
- BCF (aquatic species):
- 568.7 dimensionless
Additional information
In a weight of evidence approach with a QSAR of 6PPD and a higher homolgue substance 8PPD (1,4-Benzenediamine, N-(1-methylheptyl)-N'-phenyl-). An experimental BCF study according to OECD 305 with 8PPD yielded a BCF of 1700. Supporting information is given by a valid QSAR for the higher homologue 8PPD which yielded a BCF of 2828 showing that QSARs for this group of substances tends to overestimate the result. Therefore, the QSAR for 6PPD resulting in a BCF of 568.7 is considered realistic and even conservative.
1,4-Benzenediamine, N-(1-methylheptyl)-N'-phenyl- ("8PPD") has a similar structure as 6PPD. It is a member of the paraphenylene diamine family. The difference is that 8PPD has an C8 branched aliphatic chain, whereas 6PPD has C6 branched aliphatic chain. Therefore 8PPD is more lipophilic than 6PPD what can be seen by the octanol water coefficients (8PPD: logKow 5.74; 6PPD: logKow 4.68). 8PPD is therefore considered a worst case for the BCF of 6PPD.
Since 6PPD hydrolyses rapidly within a half life of about 8 hours, information for the hydrolysis products 4 -hydroxydiphenylamine, N-phenyl-p-benzoquinone monoimine and 1,3 -dimethylbutylamine was taken into account.A QSAR for 6PPD yielded a BCF of 568.7 indicating that the parent substance has a moderate tendency to accumulate but not meeting the criteria for B (BCF>2000) or vB (BCF >5000).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.