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Diss Factsheets
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EC number: 202-046-9 | CAS number: 91-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
In a maximisation test according to Magnusson and Kligman (OECD 406) with guinea pigs no skin sensitisation was noted (Hüls AG, 1990).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-11-27 to 1989-12-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: No positive control (not required by 1981 version of Test Guideline)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- A skin sensitization test according to OECD 406 has already excisted since 1990 and is sufficient for evaluation of the skin sensitisation potential of the test substance.
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS:
- Strain: Dunkin-Hartley (Bor: DHPW)
- Sex: female
- Source: F. Winkelmann, Borchen (Germany)
- Weight at study initiation: 375 g (mean test); 378 g (mean control)
- Housing: 1-5 animals in Makrolon-cages type IV
- Food (ad libitum): G4 Alleindiät für Meerschweinchen, Ssniff Speziealfutter GmbH, 4770 Soest
- Water (ad libitum): tap water
- Acclimation period: 5-8 days
ENVIRONMENTAL CONDITIONS:
- Temperature: 20 °C +/- 1 °C
- Humidity: 60 % +/- 5%
- Air changes: 15/ h
- Photoperiod: 12 h dark/ 12 h light - Route:
- intradermal
- Vehicle:
- other: corn oil
- Concentration / amount:
- 1st application: Induction 5 % intracutaneous
2nd application: Induction 60 % occlusive epicutaneous
3rd application: Challenge 20 % occlusive epicutaneous - Route:
- epicutaneous, occlusive
- Vehicle:
- other: corn oil
- Concentration / amount:
- 1st application: Induction 5 % intracutaneous
2nd application: Induction 60 % occlusive epicutaneous
3rd application: Challenge 20 % occlusive epicutaneous - No. of animals per dose:
- 20 test
10 control; treatment: vehicle - Details on study design:
- 1st application: Induction 5 % intracutaneous
2nd application: Induction 60 % occlusive epicutaneous
3rd application: Challenge 20 % occlusive epicutaneous
ADMINISTRATION/EXPOSURE
- Induction schedule: injection followed 1 week later by patch treatment for 48 hours
- Injection details:
0.1 ml each at 6 positions on shoulders:
2 x Freund's Complete Adjuvant / deionized water (50:50)
2 x test substance 5 % in corn oil
2 x test substance 5 % in Freund's Complete Adjuvant / corn oil (50:50)
simultaneous and symmetrical application of each solution
controls: corn oil instead of test substance
- Challenge schedule: 2 weeks after end of induction, patch treatment for 24 hours
- Concentrations used for challenge: 20 % in corn oil with filter paper on left side; corn oil on opposite side readings 24 and 48 hours after
removal of patch
- Rechallenge: no
- Positive control: no
EXAMINATIONS
- Grading system:
possible scores 0 / 1 / 2 / 3
0 % of animals scored > 0: no sensitization
1 - 8 % of animals scored > 0: very slight sensitization
9 - 28 % of animals scored > 0: slight sensitization
29 - 64 % of animals scored > 0: distinct sensitization
5 - 80 % of animals scored > 0: severe sensitization
81 -100 % of animals scored > 0: extreme sensitization - Challenge controls:
- Concentrations used for challenge:
20 % in corn oil with filter paper on left side;
corn oil on opposite side readings 24 and 48 hours after - Positive control substance(s):
- no
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 20%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 20%. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 20%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 20%. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Conclusions:
- In a dermal sensitisation study according to Magnusson and Kligman decahydronaphthalene showed no skin sensitisation in guinea pigs.
- Executive summary:
In a dermal sensitisation study according to Magnusson and Kligman a group of twenty female guinea pigs received decahydronaphthalene as 5% dilution in corn oil by the intracutaneous route followed by dermal application of the 60% solution of the test item in corn oil in the induction phase.
Challenge was with 20% decahydronaphthalene in corn oil, no skin sensitisation was observed.
Reference
RESULTS OF TEST
- Sensitization reaction:
0/20 animals positive at 24 hours and at 48 hours = no sensitization
no animals positive in control group
no skin reaction upon corn oil treatment on opposite side (both groups)
- Clinical signs:
1st induction, FCA + water application sites: erythema, edema, necroses
1st induction, test substance + vehicle application sites: erythema and edema in 20/20 animals, necroses in 3/20 animals
1st induction, FCA + test substance + vehicle application sites: erythema and edema in 20/20 animals, necroses in 13/20 animals
1st induction, FCA + vehicle application sites: erythema, edema, necroses in 7/10 animals
1st induction, vehicle application sites: erythema in 4/10 control animals
2nd induction, test and control groups: erythema and edema in all FCA + water injection sites with bleeding in some animals within
1 hour; simlar observations with lower incidence in FCA + test substance + vehicle injection sites; crust formation within 24 hours.
- Other: Mean body weight gain 136 g in test group, 132 g in control group = expected range.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Assessment of decahydronaphthalene concerning respiratory sensitisation is not possible because no data are available for this toxicological endpoint.
Justification for classification or non-classification
According to CLP Regulation 1272/2008 decahydronaphthalene is not classified as sensitizing to skin.
Classification of decahydronaphthalene concerning respiratory sensitisation is not possible because no data are available for this toxicological endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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