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Diss Factsheets
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EC number: 202-046-9 | CAS number: 91-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Decahydronaphthalene has a low acute toxicity by the oral and dermal route with an oral LD50 (rat) of 4170 mg/kg bw (Smyth et al., 1951) and a dermal LD50 (rat) of 5200 mg/kg bw (Smyth et al., 1951).
Upon inhalation exposure the LC50 was 4.08 mg/L air (MacEwen, Vernot, 1978).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949-1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study briefly summarised, meets generally accepted scientific principles, acceptable for assessment. Restrictions: no guideline, no GLP
- Principles of method if other than guideline:
- Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- water
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- 14 days observation period
- Statistics:
- Thompson, W.R. (1947): Use of moving averages and interpolation to estimate median effective dose. Bact. Rev. 11, 115
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 170 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: (3.36-5.16 g/kg bw)
- Mortality:
- LD50 = 4170 ((3.36-5.16 g/kg bw) mg/kg bw
- Clinical signs:
- other:
- Conclusions:
- The LD50 value (oral) of decahydronaphthalene in male rats was estimated to be 4170 mg/kg bw based on a 14 day observation period. Thus the test substance showed a low toxicity in rats after oral gavage.
- Executive summary:
The LD50 value (oral) of decahydronaphthalene in male rats was estimated to be 4170 mg/kg bw based on a 14 day observation period. Thus the test substance showed a low toxicity in rats after oral gavage.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 170 mg/kg bw
- Quality of whole database:
- Klimisch 2 (reliable with restrictions)
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977-06 to 1978-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, sufficient information about test material, test organisms
- Principles of method if other than guideline:
- Acute inhalation toxicity similar to OECD 403
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
Species/ Strain: rats, Sprague-Dawley
Sex: male
Source: Harlan Industries Inc. - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- 9 l glass chamber
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- hydrocarbon analyser
- Duration of exposure:
- 4 h
- Concentrations:
- 980, 820, 785, 625, 375 ppm
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - exposure to measured concentrations of the test substance to determine an 4 hour LC 50
- Duration of observation period following administration: 14 days - Statistics:
- Finney's probit analysis
- Preliminary study:
- Exposure of 5 male rats each to saturated vapours for 4, 2 and 1-hour resulted in death of 5, 5 and 2 rats respectively. The rats were hyperactive early in the exposure but after approximately 40 minutes exhibited tonic convulsions, tremors and prostration. Rats that survived two hours or more of exposure were paralysed in the posterior half of the body and this paralysis persisted for several days. None of the paralysed rats survived the 14-day postexposure observation period.
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 710 ppm
- Based on:
- test mat.
- 95% CL:
- > 619 - < 816
- Exp. duration:
- 4 h
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4.08 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: calculated
- Mortality:
- All 5 animals died at 980 ppm, dose dependend decrease of mortality with non mortalities at 375 ppm
- Clinical signs:
- other: Animals displayed tremour and convulsions followed by prostration. Most survivours displayed hind quarter paralysis
- Gross pathology:
- Mild to severe congestion of the lungs with occasional areas of atelectasis was noted in animals that died. Reticulation of the liver and pale coloration of most organs was a common finding at all concentration levels.
- Conclusions:
- LC50 was determiend at 710 ppm ( with a 95% confidence intervall of 619-816 ppm). This corresponds to 4.08 mg/L air.
- Executive summary:
Male Sprague-Dawley rate (5 per group) a were exposed for 4 hours to varying concentrations of Decalin vapor (375 -980 ppm). Animals were exposed in a 9-liter glas chamber and observed for 14-days post exposure. Chamber concentrations were analyzed using a hydrocarbon analyzer. LC50 was calculated using Finney's probit analysis method. Reticulation of the liver and pale coloration of most organs was a common finding at all concentration levels.
Animals displayed tremors and convulsions followed by prostration. Most survivors displayed hind quarter paralysis. Gross pathologic examination of animals that died showed mild to severe congestion of the lungs with occasional areas of atelectasis.
Reference
Concentration ppm | Concentration mg/L | Mortality |
980 | 5.55 | 5/5 |
820 | 4.65 | 4/5 |
785 | 4.45 | 2/5 |
625 | 3.54 | 2/5 |
375 | 2.12 | 0/5 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 4 080 mg/m³ air
- Quality of whole database:
- Klimisch 1 (reliable without restrictions)
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949-1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study briefly summarised, meets generally accepted scientific principles, acceptable for assessment. Restrictions: Only male animals used, no guideline, no GLP
- Principles of method if other than guideline:
- Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - Area covered: clipped trunk
- Occlusion: impervious flexible film ("vinylite" sheeting)
- Exposure period: 24 hours
- Observation period: 14 days - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Thompson, W.R. (1947): Use of moving averages and interpolation to estimate median effective dose. Bact. Rev. 11, 115
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 200 mg/kg bw
- 95% CL:
- 3 380 - 8 000
- Mortality:
- LD50 = 5.9 (3.84-9.06) mL/kg bw
=5200 (3380-8000) mg/kg bw - Clinical signs:
- other:
- Conclusions:
- The LD50 (rabbit) for decahydronaphthalene applied to the skin of the rabbit is 5.9 mL/kg bw (=5.2 g/kg bw). Thus decahydronaphthalene showed low acute toxicity in rabbits after dermal application.
- Executive summary:
The LD50 for decahydronaphthalene applied undiluted to the clipped skin of the rabbit trunk under "Vinylit" sheeting for 24h was 5.9 mL/kg bw (95% confidence limit 3.84-9.06). This corresponded to 5200 (3380-8000) mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 200 mg/kg bw
- Quality of whole database:
- Klimisch 2 (reliable with restrictions)
Additional information
Justification for classification or non-classification
Decahydronaphthalene has a low acute toxicity by the oral and dermal route, the experimental evidence indicates that limit values are exceeded and therefore no classification is required for acute oral and dermal toxicity according to CLP regulation 1272/2008.
Upon inhalation exposure the LC50 was 4.08 mg/L air. Thus, decahydronaphthalene has to be classified for acute inhalation toxicity according CLP regulation 1272/2008, Annex I (Category 3, H301: Toxic if inhaled).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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