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EC number: 201-240-0 | CAS number: 79-97-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- Hydrolysis as a function of pH (2004)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Storage conditions: room temperature, dark, air-tight
Storage place: Desiccator
IR spectrum of the test substance was measured before the test and after. Spectrum were consistent indicating that the test substance was stable under the storage conditions - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples taken at the start of the experiment (0 hours) and after 5 days
- Buffers:
- Prepared buffer solutions were put in an incubator and stood more than 24 hours. A pH of the buffer solutions was measured on the experimental starting day and adjusted by dropwise additional of HCl or NaOH aqueous solution as necessary. Then, the dissolved oxygen was excluded by bubbling nitrogen for approx. 5 minutes.
pH 4.0
Mixture of 4.0mL of 0.1N NaOH and 500mL of 0.1M potassium hydrogen phthalate was diluted to 100mL with ultra pure water
pH 7.0
Mixture of 296mL of 0.1N NaOH and 500mL of 0.1M KH2PO4 was diluted to 1000mL with ultra pure water
pH 9.0
Mixture of 213 mL of 0.1N NaOH and 500mL of 0.1M KCl / 0.1M H3BO3 was diluted to 1000mL with ultra pure water
Aq. solution of 0.1M potassium hydrogen phthalate:
20.42g of potassium hydrogen phthalate was diluted to 1000 mL with ultra pure water
Aq. solution of 0.1M KH2PO4:
13.61g of KH2PO4 was diluted to 1000mL with ultra pure water
Aq solution of 0.1M KCl/0.1M H3BO3
7.46g of KCl and 6.18g of H3BO3 were diluted to 1000mL with ultra pure water - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Glass flask
- Apparatus: Thermostatic water bath: Water Bath Shaker MM-10 (No.1)
- Lighting: light shielded
- Glass flasks were capped with a lid during experiments
TEST MEDIUM
- Volume used: 300mL
- Kind and purity of water: Ultra pure water
PREPARATION OF TEST SOLUTION
Test substance (200mg) was weighed, then dissolved and filled up to 20mL with acetonitrile (HPLC grade) to prepared a 10000 mg/L stock solution. A 300 µL of the stock solution (10000 mg/L) was sampled by a micro syringe and added to 300 mL of buffer solution in a gas flask (Acetonitrile 0.1% v/v). Test solutions were shaken and left for more than 2 hours. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 10 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 10 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 10 mg/L
- Number of replicates:
- 2 per pH
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- Blank test
- Statistical methods:
- None required
- Preliminary study:
- Average rate of hydrolysis
pH 4 = 0% (5 days) at 50°C
pH 7 = 4% (5 days) at 50°C
pH 9 = 4% (5 days) at 50°C - Test performance:
- Test was judged to be valid. All results satisfied the validity criteria.
- Transformation products:
- no
- % Recovery:
- > 93 - < 96
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- ca. 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 93 - < 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes - Results with reference substance:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- Hydrolysis test (Tier1) was performed at pH 4, 7 and 9. Since less than 10% of all rates of hydrolysis was observed after 5 days, the test substance was considered to be hydrolytically stable at pH 4, 7 and 9 (Half-life at 25°C > 1 year)
Reference
Table 1 Rate of hydrolysis
|
A |
B |
C |
D |
E |
|||||
Temperature °C |
Sample description |
Date of measurement (yyyy/m/d) |
Correction day |
Peak area of processed sample count |
Peak area of standard solution count |
Measured concentration of test substance mg/L |
Rate of residual |
Rate of hydrolysis |
||
50 |
Individual % |
Average % |
Individual % |
Average % |
||||||
pH 4 – 1 |
2019/6/13 |
0 |
3632.352 |
3893.565 |
9.3 |
- |
100 |
- |
0 |
|
2019/6/18 |
5 |
3734.925 |
3929.117 |
9.5 |
102 |
-2 |
||||
pH 4 – 2 |
2019/6/13 |
0 |
3720.429 |
3893.565 |
9.6 |
- |
- |
|||
2019/6/18 |
5 |
3701.957 |
3929.117 |
9.4 |
98 |
2 |
||||
pH 7 – 1 |
2019/6/13 |
0 |
3880.287 |
3893.565 |
10.0 |
- |
97 |
- |
4 |
|
2019/6/18 |
5 |
3855.598 |
3929.117 |
9.8 |
98 |
2 |
||||
pH 7 – 2 |
2019/6/13 |
0 |
3891.393 |
3893.565 |
10.0 |
- |
- |
|||
2019/6/18 |
5 |
3743.789 |
3929.117 |
9.5 |
95 |
5 |
||||
pH 9 – 1 |
2019/6/13 |
0 |
3619.607 |
3893.565 |
9.3 |
- |
97 |
- |
4 |
|
2019/6/18 |
5 |
3609.440 |
3929.117 |
9.2 |
99 |
1 |
||||
pH 9 - 2 |
2019/6/13 |
0 |
3895.651 |
3893.565 |
10.0 |
- |
- |
|||
2019/6/18 |
5 |
3699.402 |
3929.117 |
9.4 |
94 |
6 |
Concentration of standard solution: F = 10.0 mg/L
Equations:
C = A/B x F
D = C5day/C0 x 100
E = 100-D
Table 2: Recovery Test
|
A |
B |
C |
D |
|||
Sample description |
Date of measurement (yyyy/md/) |
Correction day |
Peak area of processed sample count |
Peak area of standard solution count |
Measured concentration of test substance mg/L |
Recovery rate |
|
Individual % |
Average % |
||||||
pH4 – 1 |
2019/6/13 |
0 |
3632.352 |
3893.565 |
9.3 |
93 |
95 |
pH4 – 2 |
3720.429 |
3893.565 |
9.6 |
96 |
|||
pH7 – 1 |
2019/6/13 |
0 |
3880.287 |
3893.565 |
10.0 |
100 |
100 |
pH7 – 2 |
3891.393 |
3893.565 |
10.0 |
100 |
|||
pH 9 – 1 |
2019/6/13 |
0 |
3619.607 |
3893.565 |
9.3 |
93 |
97 |
pH 9 - 2 |
3895.651 |
3893.565 |
10.0 |
100 |
Concentration of standard solution: E 10.0 mg/L
Equations
C=A/B x E
D=C/E x 100
Description of key information
OECD guideline, GLP compliant study. Hydrolysis study was conducted at pH 4, 7 and 9 over 5 days at 50°C.
The test substance was considered hydrolytically stable during the test. The result was extrapolated to show that the half-life of the substance is expected to be >1 year at 25°C at environmentally relevant pH levels.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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