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Diss Factsheets
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EC number: 221-641-4 | CAS number: 3173-72-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Skin irritation
1,5-Naphthylene diisocyanate (NDI) was slightly to moderately irritating to the skin of rabbits according to OECD TG 404 (Schuengel, 2006b). All signs were fully reversible within two weeks. No relevant systemic intolerance reactions were observed. In addition, a test using an artificial 3D-Skin model (OECD TG 431) revealed no corrosive properties of NDI in vitro (Vohr, 2006).
According to classification criteria NDI is not an irritant to the skin.
Eye irritation
NDI was slightly irritating to the eyes of rabbits according to OECD TG 405 (Schuengel, 2006c). In all animals redness of conjunctivae were fully reversible within three days. No systemic intolerance reactions were observed.
According to classification criteria NDI is not an irritant to the eyes.
Respiratory irritation
During acute inhalation testing NDI revealed concentration-dependent signs suggestive of irritation of the respiratory tract at concentrations of 96 mg/m3and higher (Pauluhn, 1995).
Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin irritation
Classified under Annex I of Directive 67/548/EEC with R38 (irritating to skin). This classification corresponds to Category 2 (H315: Causes skin irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this no classification for skin irritation is required according to Annex I of Regulation (EC) No 1272/2008 based on the results of a dermal irritation/corrosion study on rabbits (OECD TG 404).
Eye irritation
Classified under Annex I of Directive 67/548/EEC with R36 (irritating to eye). This classification corresponds to Category 2 (H319: Causes serious eye irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this no classification for eye irritation is required according to Annex I of Regulation (EC) No 1272/2008 based on the results of an eye irritation study on rabbits (OECD TG 405).
Respiratory irritation
Classified under Annex I of Directive 67/548/EEC with R37 (irritating to respiratory system). This classification corresponds to STOT-SE Category 3 (H335: May cause respiratory irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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