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Diss Factsheets
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EC number: 247-019-2 | CAS number: 25481-21-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Remarks:
- Experimental data of read across substances
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- WoE report is based on three studies of toxicity to aquatic algae as-
WoE 2, WoE 3 and WoE 4. - GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: WoE 2: microcystis aeruginosa, WoE 3: scenedesmus capricornutum, WoE 4: Pseudokirchnerella subcapitata
- Details on test organisms:
- Common Name: Geen algae
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- 72 hr to 8 days
- Nominal and measured concentrations:
- WoE 2, WoE 3: No data available
WoE 4: 60, 80, and 100 mg/l - Reference substance (positive control):
- not specified
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Test chemical was found to be non toxic.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of toxicity to green algae the 72 hr EC50 value was determined to be > 100 mg/l.
- Executive summary:
Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on aquatic algae. The studies are as mentioned below:
First study was of toxicity to aquatic algae. Duration of study was 8 days. Microcystis aeruginosa a freshwater cyanobacteria was taken as test organism. On the basis of toxicity to freshwater cyanobacteria ( Microcystis aeruginosa) the 8 days EC0 and EC50 value was determined to be 76 mg/l and > 76 mg/l respectively.
Second study includes of toxicity to aquatic algae study. Duration of study was 72 hr. Selenastrum capricornutum a freshwater green algae was taken as test organism. On the basis of toxicity to green algae (Selenastrum capricornutum) the 72 hr EC50 value was determined to be > 72.7 mg/l.
Study of toxicity to aquatic algae was carried out in accordance with OECD 201. Duration of study was 72 hr. Green algae Pseudokirchnerella subcapitata, was taken as test organism. Nominal concentrations of 60, 80, and 100 mg/l were used, during the test the concentrations were measured by HPLC. On the basis of toxicity to growth rate of green algae Pseudokirchnerella subcapitata, 72 hr NOEC and EC50 value was determined to be 79. 4 and > 100 mg/l respectively. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of toxicity to green algae the 72 hr EC50 value was determined to be > 100 mg/l. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria.
Reference
Description of key information
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of toxicity to green algae the 72 hr EC50 value was determined to be > 100 mg/l.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
Additional information
Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on aquatic algae. The studies are as mentioned below:
First study was of toxicity to aquatic algae. Duration of study was 8 days. Microcystis aeruginosa a freshwater cyanobacteria was taken as test organism. On the basis of toxicity to freshwater cyanobacteria ( Microcystis aeruginosa) the 8 days EC0 and EC50 value was determined to be 76 mg/l and > 76 mg/l respectively.
Second study includes of toxicity to aquatic algae study. Duration of study was 72 hr. Selenastrum capricornutum a freshwater green algae was taken as test organism. On the basis of toxicity to green algae (Selenastrum capricornutum) the 72 hr EC50 value was determined to be > 72.7 mg/l.
Study of toxicity to aquatic algae was carried out in accordance with OECD 201. Duration of study was 72 hr. Green algae Pseudokirchnerella subcapitata, was taken as test organism. Nominal concentrations of 60, 80, and 100 mg/l were used, during the test the concentrations were measured by HPLC. On the basis of toxicity to growth rate of green algae Pseudokirchnerella subcapitata, 72 hr NOEC and EC50 value was determined to be 79. 4 and > 100 mg/l respectively. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of toxicity to green algae the 72 hr EC50 value was determined to be > 100 mg/l. As per the value of EC50, the test chemical was considered as not classified as per CLP criteria.
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