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Diss Factsheets
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EC number: 308-506-6 | CAS number: 98072-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
No information on animal testing of "Matte, precious metal" is available. However, Matte, precious metal 1 with a lead and lead compound content of ≥ 0.05 % and < 0.5 % and a cadmium sulfide content of ≥ 0.1 % and 1 % is considered to be toxic to specific target organs following repeated dosing via oral and inhalation route and should be labelled with STOT-RE 2; H373.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Substance specific information for the UVCB substance "Matte, precious metal" is not available for the endpoint "Repeated Dose Toxicity". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as a specific target organ toxicant that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.9.3.4 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.
In total, tree different grades of "Matte, precious metal" (Matte, precious metal 1 – Matte, precious metal 3) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile.Thus, for "Matte, precious metal" two C&L entries (i.e., STOT RE 1 and STOT RE 2) for repeated dose toxicity were calculated. Each group is described in a separate endpoint study record and endpoint summary.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
i.e., lead and lead compounds
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
i.e., cadmium sulfide
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
i.e., cadmium sulfide
Justification for classification or non-classification
Classification driver for STOT RE 2 are:
(i) Lead and lead compounds - oral
STOT RE 1; H372: C ≥ 0.5 %
STOT RE 2; H373: 0.05 % ≤ C < 0.5 %
(ii) Cadmium sulfide – oral and inhalation
STOT RE 1; H372: C ≥ 10 %
STOT RE 2; H373: 0.1 % ≤ C < 10 %
Classification of UVCB substances as being toxic to specific target organs is based on the presence of one or more constituents ≥ 1 % classified for STOT RE 1 and the presence of one or more constituents ≥ 10 % classified for STOT RE 2. However, for lead compounds and cadmium sulfide there are specific concentration limits given for STOT RE classification assigned by the lead industry and according to Regulation (EC) 1272/2008 Annex VI, respectively. According to this previously mentioned regulation “specific concentration limits” should take precedence over any other concentration limits for the purpose of classification. Hence, the SCLs for lead compounds and cadmium sulfide are used for C&L of Matte, precious metal 1. Since, Matte, precious metal 1 contains ≥ 0.05 % but < 0.5 % lead and lead compounds and 0.1 – 1 % cadmium sulfide, Matte, precious metal 1 meets the classification criteria for STOT RE 2 (H373) as required in accordance with Regulation (EC) 1272/2008.
It is noted, that no registrants are using Matte, precious metal with a cadmium/cadmium sulphide content of ≥ 0.1 %. The maximum cadmium content in Matte, precious metal is 0.09% (for detailed information please refer to the ID card attached on IUCLID section 13).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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