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EC number: 273-925-2 | CAS number: 69227-11-8 A scum formed on the surface of molten copper.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Animal testing on UVCB with variable composition is not relevant. The toxicokinetics, metabolism and distribution are driven by the characteristics of the individual UVCB constituents.
Key value for chemical safety assessment
Additional information
The toxicokinetics, metabolism and distribution are driven by the characteristics of the individual UVCB constituents.
The physico-chemical characterisation of the UVCB (see relevant section in IUCLID) demonstrates that metal constituents are built into complex mineralogical structures consisting mainly: intermetallic and metal oxides that are formedduring the removal of copper from molten lead during the pyrometallurgical refining of both primary and secondary lead bullion.This resulted in relatively high solubilisation potential in water for most of the metals present in the UVCB (e. g. Cu, Ag, As).
Generally, the physical form and the physical-chemical properties of the UVCB substance are expected to limit the solubility of the UVCB constituents in biological fluids and subsequently to limit cellular absorption of the released metals. The toxicokinetics of the UVCB is therefore primarily related to the degree to which the metal mineral phases in the UVCB react with biological fluids and release soluble, potentially bio available species. The metals in the UVCB are considered fully soluble in water and therefore the bio-accessibility of the metal ion is considered as equivalent to the bio-accessibility/bio-availability of soluble metal compounds (Me sulfates and oxides).
In addition, the following requires to be taken into consideration:
Oral: the UVCB is a powder and needs to dissolve before it can be adsorbed. Relatively high absorption in gastro intestinal tract can therefore be expected due to (anticipated) full solubility of constituting species.
Inhalation: Three samples were tested and a D50 of 200, resp. 56 and 99 µm was determined and thus contains the UVCB inhalable particles (particle size less than 100 µm), which are capable of entering the respiratory tract under realistic breathing conditions.
Dermal: the UVCB has to dissolve into the surface moisture of the skin before dermal uptake can begin. As the UVCB is highly soluble in water, it is expected to partition much to the epidermis, and thus likely resulting in substantial dermal uptake of some constituting (metal) species. The metals adsorbed after dermal exposure may also contribute to systemic metal doses and therefore have been considered for the (combined) toxicity assessment, as appropriate.
The “bio accessible” metal ions may enter the blood stream and exert its toxic action directly to the blood or in any target tissue or organ to which the circulatory system transports or distributes it. Information on toxicokinetics (absorption, distribution, metabolism and excretion) is available for key metal constituents in the UVCB. Metal-specific oral bio-availability of soluble compounds are therefore applicable to the UVCB.
The following information is taken into account for any hazard / risk assessment:
Animal testing on UVCB with variable composition is not relevant. The toxicokinetics, metabolism and distribution are driven by the characteristics of the individual UVCB constituents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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