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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 211-128-3 | CAS number: 630-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
GLP-compliant bacterial gene mutation (Ames, using 5 S.typhimur and 1 E.coli strain) and in vitro mammalian gene mutation (mouse lymphoma L5178Y) test in the absence and presence of S9 were conducted. Results from both tests confirmed carbon monoxide was negative when tested up to 100%(v/v) (Ames) or 70% (v/v) (maximum practicable concentration in the mouse lymphoma assay).
A rat repeat dose inhalation (28 day) GLP-compliant study was conducted in which the bone marrow was harvested and collected at the end of the study to address the micronucleus endpoint. It should be noted that due to continual bone marrow turn over, bone marrow analysis was restricted to a 48 hour exposure (dosing on days 27 and 28, with necropsy on day 29), rather than a true dosing regimen over a period of 1 to 28 days (if the true effects of exposure to CO were to be examined following a 28 day exposure, concurrent peripheral blood micronucleus analysis (pre dose, day 4 and day 29) should have been undertaken to assess potential accumulation and toxicity). However, the micronucleus endpoint has been adequately addressed using this protocol design.
Under REACH, the integrated testing strategy for mutagenicity states that if no data from an in vitro cytogenetic study is available, the study does will not need to be conducted if adequate data from an in vivo cytogenetic study is available. The negative results obtained for the bacterial gene mutation test, in vitro mammalian gene mutation test and in vivo rat micronucleus study confirm that no further testing is required and carbon monoxide is concluded to be devoid of genotoxic potential.
Short description of key information:
Bacterial reverse gene mutation test - May, K (2004) VAB009
In vitro mammalian gene mutation test - Soanes, E (2004) VAB010
In vivo rat micronucleus test - Mason, C (2004) VAB008
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
There was no evidence of genotoxicity in studies with carbon monoxide; therefore carbon monoxide has not been classified as genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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