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EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16.04.1999- 20.07.2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: BBA Guidelines, Part IV, 5-1
- Qualifier:
- according to guideline
- Guideline:
- other: SETAC Europe, Part 8.2
- Qualifier:
- according to guideline
- Guideline:
- EPA Subdivision N Pesticide Guideline 162-4 (Aerobic Aquatic Metabolism)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- yes
- Remarks:
- both radiolabelled forms of BAS 421F, phenyl-[14C] and morpholine-[14C] were used and applied
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment: freshwater
- Details on source and properties of surface water:
- System A : Kellmetschweiher, Rhineland-Palatinate, FRG
pH: 8.42
hardness (mmol/l): 1.44
TOC (mg/l): 10.1
total N (mg/l): 3
total P (mg/l): <3
System B : Ranschgraben, Rhineland-Palatinate, FRG
pH: 7.85
hardness (mmol/l): 1.04
TOC (mg/l): 3.1
total N (mg/l): 5
total P (mg/l): <3 - Details on source and properties of sediment:
- System A : Kellmetschweiher; Rhineland-Palatinate, FRG
sand (%): 85
silt (%): 7
clay (%): 8
textural class (German scheme): clayey sand / loamy sand
pH (CaCl2): 7.4
organic C (%): 1.0
total N (%): 0.07
total P (%): 0.008
CEC (mVal/100g): 15
ATP (µg/kg): 45
plate counts (cfu/g)
bacteria: 1.8 x 10^6
actinomycetes: 3.9 x 10^4
fungi: 1.4 x 10^3
System B : Ranschgraben, Rhineland-Palatinate, FRG
sand (%): 79
silt (%): 16
clay (%): 5
textural class (German scheme): silty sand / loamy sand
pH (CaCl2): 5.4
organic C (%): 5.3
total N (%): 0.41
total P (%): 0.12
CEC (mVal/100g): 20
ATP (µg/kg): 1531
plate counts (cfu/g)
bacteria: 8.0 x 10^6
actinomycetes: 1.8 x 10^6
fungi: 9.0 x 10^4 - Details on inoculum:
- 75 µg of 14C-BAS 421 F were applied per test vessels which corresponds to a eld application rate of 750 g BAS 421 F per hectare. The concentration in the test system was about 250 µg/l.
- Duration of test (contact time):
- 100 d
- Initial conc.:
- 250 µg/L
- Based on:
- test mat.
- Details on study design:
- BAS 421 F was applied to the water at a rate of 75 µg a.s. per test vessel which corresponded to the maximum recommended rate of 750 g as/ha when related to a 30 cm deep water body. Experiments under sterile conditions were also carried out in both water/sediment systems. For the isolation and identification of degradation products, some water/sediment systems were additionally treated at an application rate of 200 µg a.s. per test vessel. The test vessels were incubated in the dark at a temperature of 20 ± 2 °C for up to 100 days. Aeration was achieved by a stream of air over the water surface. A trapping system for volatiles was connected to each test vessel (except the sterilised vessels).
- Compartment:
- natural water / sediment: freshwater
- % Recovery:
- 92.6
- Key result
- Compartment:
- natural water / sediment: freshwater
- DT50:
- 54 d
- St. dev.:
- 0.99
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 20 °C
- Remarks on result:
- other: Kellmetschweiher system
- Remarks:
- in whole system
- Key result
- Compartment:
- natural water: freshwater
- DT50:
- 3.4 d
- St. dev.:
- 0.98
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 20 °C
- Remarks on result:
- other: Kellmetschweiher system in water compartment
- Key result
- Compartment:
- natural sediment: freshwater
- DT50:
- 83.6 d
- St. dev.:
- 0.98
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 20 °C
- Remarks on result:
- other: Kellmetschweiher system
- Remarks:
- in sediment compartment
- Key result
- Compartment:
- natural water / sediment: freshwater
- DT50:
- 18 d
- St. dev.:
- 0.99
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 20 °C
- Remarks on result:
- other: Ranschgraben system
- Remarks:
- in whole system
- Key result
- Compartment:
- natural water: freshwater
- DT50:
- 1.9 d
- St. dev.:
- 0.98
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 20 °C
- Remarks on result:
- other: Ranschgraben system
- Remarks:
- in water compartment
- Key result
- Compartment:
- natural sediment: freshwater
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 20 °C
- Remarks on result:
- not determinable
- Remarks:
- Ranschgraben system in sediment compartment
- Transformation products:
- yes
- No.:
- #1
- Volatile metabolites:
- no
- Details on results:
- The results from the two different radiolabels revealed no sigificant differences; therefore the differently radiolabelled replicates were averaged. The distribution and recovery of radioactivity from water/sediment system A is shown in Table 1, the corresponding results from system B are presented in Table 2.
In both systems, the radioactivity moved quite fast from the water into the sediment. However, in system A, the radioactivity increased again from 17% TAR to 29% TAR in the time period from 29 to 100 days. This indicates that a metabolite formed in the sediment moved back into the water. In system B, the same phenomenon seems to appear, however, after a short increase of the radioactivity in the water, it decreased further down to 12% TAR at the end of the study. Mineralisation was moderate in both systems reaching 6.3 and 8.5% TAR (system A/B) and no other volatile degradates were detected.
In system A, the bound residues in the sediment increased slowly reaching about 20% TAR at the end of the study. In system B, the bound residues reached about 28% after 29 days, but then decreased again to 37% TAR at the end of the study.
A comprehensive overview on the results of the HPLC analysis of the water and of the extracts of sediment is shown in Table 3 for system A and in Table 4 for system B.
Fenpropimorph (BAS 421 F) and the metabolite fenpropimorph-acid (BF 421-2) were the major compounds in both water/sediment systems. In the water phase, the metabolite fenpropimorph-acid reached maximum amounts of about 23 / 17% TAR (system A/B). In the sediment, the metabolite appeared only at the last three sampling times and only in amounts <8% TAR. Since the radioactivity in the water phase first decreases, but then increases again, it can be assumed that at least a major part of the fenpropimorph-acid was formed in the sediment and moved back into the water.
Mathematical evaluation of the disappearance of fenpropimorph and metabolite fenpropimorph-acid was performed using the computer program ModelMaker, version 3.0.4. - Conclusions:
- Fenpropimorph has a low water solubility and a high adsorption coefficient, which leads to a fast movement into the sediment. Within the sediment, fenpropimorph is oxidised to the metabolite fenpropimorph-acid, which has a much better solubility and a weaker adsorption. Therefore fenpropimorph-acid moves back to the water phase and is mainly found in it. It can further be metabolized and the final mineralisation to CO2 to 6% to 8% of the applied radioactivity is significant. The amounts of bound residues are moderate.
Reference
Table 1: Material balance and distribution of radioactivity after application of (14C)-fenpropimorph to water/sediment system A (%TAR) | ||||||||
DAT |
water | sediment |
CO2 |
balance | ||||
extractable residues | bound residues | total | ||||||
ACN/H2O | ACN | total | ||||||
|
|
|
|
|
|
|
|
|
0 0.25 1 2 7 14 29 63 100 | 70.5 77.0 61.3 46.5 23.9 17.4 16.8 26.1 28.8 | 4.6 3.6 7.2 10.9 14.9 17.7 16.7 19.2 20.2 | 8.8 5.6 14.3 20.6 32.4 32.2 30.7 20.6 16.9 | 13.4 9.3 21.4 31.6 47.3 49.9 47.4 39.9 37.1 | 6.7 4.7 9.7 14.8 23.9 26.6 27.5 23.6 20.0 | 20.1 14.0 31.1 46.4 71.2 76.5 75.0 63.5 57.1 | n.d. 0.0 0.0 0.1 0.4 0.7 1.7 4.5 6.3 | 90.6 91.0 92.4 93.0 95.4 94.7 93.4 94.1 92.2 |
101 s | 4.5 | 37.2 | 35.2 | 72.5 | 15.5 | 88.0 | n.d. | 92.4 |
s = sterilised
n.d. = not determined
Table 2: Material balance and distribution of radioactivity after application of (14C)-fenpropimorph to water/sediment system B (%TAR) | ||||||||
DAT |
water | sediment |
CO2 |
balance | ||||
extractable residues | bound residues | total | ||||||
ACN/H2O | ACN | total | ||||||
|
|
|
|
|
|
|
|
|
0 0.25 1 2 7 14 29 63 100 | 75.0 73.3 50.3 39.0 23.5 19.0 21.4 17.6 12.0 | 3.4 3.6 8.0 10.0 12.4 13.7 13.8 14.1 14.2 | 8.2 8.0 20.8 24.2 32.3 31.2 22.8 17.3 20.3 | 11.7 11.7 28.8 34.2 44.8 45.0 36.6 31.5 34.5 | 5.9 6.3 12.7 17.7 24.4 27.2 30.1 36.4 36.8 | 17.5 17.9 41.5 51.9 69.2 72.2 66.6 67.9 71.3 | n.d. 0.0 0.1 0.1 0.7 2.0 4.1 7.5 8.5 | 92.5 91.2 91.9 91.0 93.3 93.1 92.1 93.1 91.9 |
101 s | 5.2 | 27.4 | 41.4 | 68.7 | 19.7 | 88.4 | n.d. | 93.6 |
s = sterilised
n.d. = not determined
Table 3: HPLC analysis of the water and the extracts of the sediment of system A after application of (14C)-fenpropimorph (%TAR) | ||||
DAT | fenpropimorph | fenpropimorph-acid | others | total |
|
|
|
|
|
water |
|
|
|
|
0 0.25 1 2 7 14 29 63 100 | 70.1 73.5 60.1 43.4 19.8 7.6 4.5 3.0 2.7 | 0.0 0.0 0.0 0.0 1.7 6.5 9.3 20.5 22.6 | 0.4 3.4 1.2 3.1 2.4 3.4 3.0 2.6 3.5 | 70.5 77.0 61.3 46.5 23.9 17.4 16.8 26.1 28.8 |
101 s | 2.3 | 0.0 | 2.2 | 4.5 |
sediment |
|
|
|
|
0 0.25 1 2 7 14 29 63 100 | 13.2 9.3 20.9 30.0 46.9 48.2 46.2 34.7 28.2 | 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.1 7.7 | 0.1 0.0 0.5 1.6 0.4 1.7 1.1 1.1 1.2 | 13.4 9.3 21.4 31.6 47.3 49.9 47.4 39.9 37.1 |
101 s | 72.5 | 0.0 | 0.0 | 72.5 |
s = sterilised
Table 4: HPLC analysis of the water and the extracts of the sediment of system B after application of (14C)-fenpropimorph (%TAR) | ||||
DAT | fenpropimorph | fenpropimorph-acid | others | total |
|
|
|
|
|
water |
|
|
|
|
0 0.25 1 2 7 14 29 63 100 | 73.5 68.9 48.6 36.1 9.1 4.5 2.0 0.7 1.0 | 0.0 0.0 0.0 0.0 7.5 10.9 16.9 14.0 8.6 | 1.5 4.3 1.7 2.9 6.8 3.6 2.5 3.0 2.4 | 75.0 73.3 50.3 39.0 23.5 19.0 21.4 17.6 12.0 |
101 s | 2.6 | 0.0 | 2.6 | 5.2 |
sediment |
|
|
|
|
0 0.25 1 2 7 14 29 63 100 | 11.5 11.7 28.8 33.3 44.8 44.6 32.0 25.7 27.4 | 0.0 0.0 0.0 0.0 0.0 0.0 4.3 5.2 5.7 | 0.1 0.0 0.0 1.0 0.0 0.4 0.3 0.6 1.3 | 11.7 11.7 28.8 34.2 44.8 45.0 36.6 31.5 34.5 |
101 s | 67.6 | 0.0 | 1.1 | 68.7 |
s = sterilised
Table 5: Dissipation rates of fenpropimorph in water sediment systems | |||
System A (Kellmetschweiher) | DT50 (days) | DT90 (days) | r2 |
|
|
|
|
fenpropimorph (BAS 421 F) (water) | 3.4 | 11.1 | 0.98 |
fenpropimorph (BAS 421 F) (sediment) | 83.6 | 1) | 0.98 |
BAS 421 (total system) | 54 | 1) | 0.99 |
fenpropimorph-acid (BAS 421-2) (water) | 120.7 | 1) | 0.98 |
| |||
System B (Ranschgraben) | DT50 (days) | DT90 (days) | r2 |
|
|
|
|
fenpropimorph (BAS 421 F) (water) | 1.9 | 6.4 | 0.98 |
fenpropimorph (BAS 421 F) (sediment) | 2) | 2) | 0.98 |
BAS 421 (total system) | 18 | 1) | 0.99 |
fenpropimorph-acid (BAS 421-2) (water) | 38.7 | 1) | 0.98 |
1) value > 2 times study duration
2) no estimation possible
Description of key information
Fenpropimorph has a low water solubility and a high adsorption coefficient, which leads to a fast movement into the sediment. Within the sediment, fenpropimorph is oxidised to the metabolite fenpropimorph-acid, which has a much better solubility and a weaker adsorption. Therefore fenpropimorph-acid moves back to the water phase and is mainly found in it. It can further be metabolized and a final mineralisation to CO2 to 6% to 8% of the applied radioactivity is reached. The amounts of bound residues are in System A 20.0 % and in system B 36.8 %.
The DT50 values for the two total systems were 54 and 18 days, forming a mean value of 36 days. For the water phase DT50 values of 1.9 and 3.4 days were detremined, resulting in a mean value of 2.65 days, compare BASF key study 2000/10000146.
The DT50 values of the metabolite fenpropimorph-acid in the two water phases were 39 and 121 days (2000/1000146).
Key value for chemical safety assessment
- Half-life in freshwater:
- 2.65 d
- at the temperature of:
- 20 °C
- Half-life in freshwater sediment:
- 31.2 d
- at the temperature of:
- 20 °C
Whole System
- Half-life in whole system:
- 36 d
- at the temperature of:
- 20 °C
- Type of system:
- fresh water and sediment
Additional information
The geometric mean degradation half-life of fenpropimorph in fresh water systems was found to be 2.5 days.
The half-life of fenpropimorph in one of the sediment systems was found to be 83.6 days; for the other system no DT50 value could be determined since it exceded the duration of the study of 100 days.
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