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EC number: 866-700-0 | CAS number: 2102522-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Remarks:
- Dissociated/undissociated form calculated from the variation of retention time.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 June 2018 - 11 September 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The dissociation constants (pKa) in water of the test material could not be measured according to the titration method, the spectrophotometric method and the conductometric method in the OECD 112, because the water solubility of the test material was low. Therefore, in this study, the retention time of the test material was measured by the HPLC analysis using the eluents of various pH and then the dissociated/undissociated form of the test material was evaluated from the variation of the retention time.
- GLP compliance:
- no
- Remarks:
- not required for physico-chemical studies
- Specific details on test material used for the study:
- - Storage conditions: The test material was stored in a dark storage place at room temperature.
- Dissociating properties:
- no
- Remarks on result:
- other: Test material has an undissociated form in the pH range of 3.0 - 9.0.
- Conclusions:
- Under the conditions of this study, the test material has an undissociated form in the pH range from 3.0 - 9.0.
- Executive summary:
The dissociation constants (pKa) in water of the test material could not be measured according to the titration method, the spectrophotometric method and the conductometric method in the OECD 112, because the water solubility of the test material was low. Therefore, in this study, the retention time of the test material was measured by the HPLC analysis using the eluents of various pH and then the dissociated/undissociated form of the test material was evaluated from the variation of the retention time.
The retention time of the test material was almost constant in pH 3.0 to pH 9.0. Therefore, under the conditions of this study, the test material has an undissociated form in the pH range from 3.0 - 9.0.
Reference
Overall results
pH of buffer solution |
Retention time (min) |
||
Measured value |
Average |
||
3.0 |
7.08 |
7.06 |
7.07 |
7.0 |
6.96 |
6.96 |
6.96 |
9.0 |
6.95 |
6.95 |
6.95 |
Description of key information
The test material has an undissociated form in the pH range from 3.0 - 9.0.
Key value for chemical safety assessment
Additional information
The dissociation constants (pKa) in water of the test material could not be measured according to the titration method, the spectrophotometric method and the conductometric method in the OECD 112, because the water solubility of the test material was low. Therefore, in this study, the retention time of the test material was measured by the HPLC analysis using the eluents of various pH and then the dissociated/undissociated form of the test material was evaluated from the variation of the retention time.
The retention time of the test material was almost constant in pH 3.0 to pH 9.0. Therefore, under the conditions of this study, the test material has an undissociated form in the pH range from 3.0 - 9.0.
The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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