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Diss Factsheets
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EC number: 942-063-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 10.01.2012 to 07.02.2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- study performed with N-cocoyl glycine sodium salt
- Justification for type of information:
- Hostapon SG and Acylglycinate GCK-12H-T are structurally closely related UVCB substances, which differ predominantly in the counterion (sodium resp. potassium). As the counter-ion itself is not expected to have any significant adverse effect contributing to substance toxicity, it can be assumed that the results obtained with Hostapon SG for this specific endpoint also apply to Acylglycinate GCK-12H-T.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Dr. U. Noack-Laboratorien, Käthe-Paulus-Straße 1, D-31157 Sarstedt, Germany
Test material
- Reference substance name:
- Glycine, N-coco acyl derivs., sodium salts
- EC Number:
- 291-350-5
- EC Name:
- Glycine, N-coco acyl derivs., sodium salts
- Cas Number:
- 90387-74-9
- Molecular formula:
- Molecular formula for this UVCB is not available.
- IUPAC Name:
- Glycine, N-coco acyl derivs., sodium salts
- Test material form:
- solid - liquid: aqueous solution
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and of test material: Clariant Produkte (Deutschland) GmbH, Corporate Product Stewardship, Am Unisys-Park 1, D- 65843 Sulzbach am Taunus, Germany
STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, protected from light, in original container
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no
FORM AS APPLIED IN THE TEST (if different from that of starting material): Hostapon SG is a colourless aqueous liquid and was tested as such
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Laboratory culture: no
- Name and location of sewage treatment plant where inoculum was collected: Municipal sewage treatment plant of D-31137 Hildesheim (Germany)
- Preparation of inoculum for exposure: The activated sludge was washed twice with autoclaved tap water and concentrated to a dry sludge concentration of 3.0 g/L +/- 10%
- Pretreatment: no
- Initial biomass concentration: 3.05 g dry solids/L sludge; dry solid concentration in test solution: 1.53 g/L
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20.5°C
- pH:
- 7.5 +/-0.5
- Dissolved oxygen:
- >=60% of air saturation
- Nominal and measured concentrations:
- 100, 180, 320, 580, and 1000 mg a.i./L nominal
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Erlenmeyer flask
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass/1000 mL/-/500 mL
- Aeration: aeration of test vessels by shaking
- No. of vessels per concentration (replicates): 5
- No. of vessels per control (replicates): 6
- No. of vessels per vehicle control (replicates): no vehicle used
- Sludge concentration (weight of dry solids per volume): 3.05 g dry solids/L sludge
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: nutrient solution: synthetic waste water according to OECD Guideline 209
OTHER TEST CONDITIONS
- Adjustment of pH: no
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): respiration inhibition
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8
- Justification for using fewer concentrations than requested by guideline: -
- Range finding study: performed
- Test concentrations: 10, 100, and 1000 mg a.i./L
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- yes
- Remarks:
- Copper (II) sulphate pentahydrate p.a.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- 372 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 791 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Results with reference substance (positive control):
- The EC50 for respiration inhibition with the reference item copper (II) sulphate pentahydrate yielded a value of 129 mg/L. This value was within the validity range of 53-155 mg/L and thus the validity criterion for this aspect is fulfilled..
- Reported statistics and error estimates:
- The NOEC was determined determined via one way analysis of variance and Dunett's test. The EC-values of the Hostapon SG were calculated by sigmoidal dose-respnse regression. The EC50-value of the reference item was calculated by linear regression using the software GraphPad Prism5, GraphPad Software, Inc..
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC-, EC10, and EC50-values for the respiration inhibition of Hostapon SG were determined to be 320, 372, and 791 mg a.i./L nominal. As Hostapon SG and acylglycinate GCK-12H-T differ only in the counterion (sodium-potassium), it can be assumed that the obtained results with Hostapon SG also apply to acylglycinate GCK-12H-T.
- Executive summary:
The toxicity of Hostapon SG to activated sludge was investigated in a study conducted according to OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test). Activated sludge from a municipal sewage treatment plant treating predominantly domestic waste was exposed to Hostapon SG at different concentrations (range: 100 to 1000 mg a.i./L nominal). After 3 h of incubation the inhibition of respiration was determined in comparison to a set of test solutions without any test substance. The NOEC value for inhibition of total respiration was determined to be 320 mg a.i./L nominal, respectively. The corresponding EC10 and EC50 values were 372 and 791 mg a.i./L nominal, respectively. As Hostapon SG and acylglycinate GCK-12H-T differ only in the counterion (sodium-potassium), it can be assumed that the obtained results with Hostapon SG also apply to acylglycinate GCK-12H-T.
The study is regarded as reliable with restriction and satisfies the requirements of the guideline. The restriction is based on the fact that the results were not obtained with the test item here under investigation but from a very similar substance.
Results Synopsis
Test organism: activated sludge from a municipal sewage treatment plant
NOEC: 320 mg a.i./L
EC10: 372 mg a.i./L
EC50: 791 mg a.i./L (nominal each)
Endpoint(s) Effected: respiration
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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