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EC number: 700-693-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Ready result with OECD closed bottle test + additional literature info to support this result
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Alkyl polypropylene polyamines are biocidal to micro-organisms and consequently inhibitory in all ready biodegradability tests. Inhibition by test substances in ready biodegradability tests is best detected prior to the onset of the biodegradation of the test substance through suppression of the endogenous respiration (lower oxygen consumption in the presence of a test substance as compared to the control). In a standard test, inhibition by Coco dipropylene triamine(C8-18dipropylene triamine)was still noted at day 14.The biodegradation of Coco dipropylene triamine(C8-18dipropylene triamine)started at day 21 (van Ginkel et al, 2009).Inhibitory effects of fatty amine derivatives increase with increasing chain lengths unless the substance becomes unavailable (Dean Raymond and Alexander 1977; van Ginkel, 1995). In view of the difficulty to demonstrate the true biodegradability of Coco dipropylene triamine(C8-18dipropylene triamine)in the Closed Bottle test it is very unlikely that justifiable results can be obtained in ready biodegradability tests with longer chain alkyl dipropylene triamines. For very toxic substances, the specified high test substance concentrations are controversial, because substances are present in the environment in the sub μg l-1 range. The true biodegradability of long-chain alkyl dipropylene triamines can therefore only be assessed through read across using extrapolation.
Coco dipropylene triamine, (C8-18dipropylene triamine;“short-chain alkyl”) is the only alkyl dipropylene triamine available which can be used for proper ready biodegradability testing. Coco dipropylene triamine(C8-18dipropylene triamine)tested in the presence of silica gel was biodegraded 75% at day 28 in the Closed Bottle test. Hence this substance should be classified as readily biodegradable (AkzoNobel GLP report, 2009). Dipropylene triamine is a chemical consisting of a hydrophilic group linked to a hydrophobic moiety. Biodegradation of both moieties of surfactants require the concerted action of at least two micro-organisms as a single organism usually lacks the full complement of enzymatic capabilities (van Ginkel, 1996). In ready biodegradability tests, the two moieties of this fatty amine derivative are therefore degraded sequentially. The degradation curve will therefore be the sum of two growth curves. The biodegradation of the two moieties may be fully in line with the time-day window criterion when judged as separate chemicals. The time window criterion was developed on the assumption that a compound is degraded according to the “standard” growth curve in ready biodegradability tests. The time-window should therefore be ignored as a pass fail criterion for these surfactants.
Chemically alkyl dipropylene triamines have an alkyl group linked directly to a primary nitrogen atom of dipropylene triamines through a covalent bond. The alkyl group may be derived from Dodecyl (C12), Coco (C8-18), Tallow (C12-18), or Oleyl (C18). Biodegradation of surfactants refer to the reduction in complexity of the chemical through metabolic activity of micro-organisms utilizing the substance as carbon and energy source. If a surfactant is to serve as a carbon and energy source for aerobic micro-organisms it has to be converted into a form that is capable of entering the central metabolism of micro-organisms. Normally this involves converting the surfactant into one, or more, low molecular weight intermediates of the tricarboxylic acid (TCA) cycle or compounds that feed into it. These conversions are described in pathways for cationic surfactants (van Ginkel, 2007). Although micro-organisms capable of degrading surfactants are immensely diverse, the central metabolism (b-oxidation and TCA cycle) is remarkably similar. Kluyver and Donker (1926) first described this similarity known as the unity of biochemistry. This unity is the key to justification of the use of read-across of biodegradability test results. Detailed studies with fatty amine derivatives imply that complete mineralisation is achieved by consortia of alkyl chain utilizing and hydrophilic moiety degrading micro-organisms (van Ginkel 1996). Most surfactant degrading consortia interact commensalistically through production and release of the hydrophilic part of the molecule by alkyl chain degrading bacteria. Another organism utilizes the hydrophilic moiety released as growth substrate.
The most plausible biodegradation pathway of alkyl dipropylene triamine is an attack on the hydrophobic part of the molecule followed by the degradation of dipropylene triamine. The alkyl chain is degraded through the b-oxidation cycle. In each cycle, the alkyl chain is progressively shortened by two carbons yielding one molecule of acetyl-CoA. The acetyl-CoA generated in b-oxidation enters the TCA cycle, where it is further oxidised to carbon dioxide and water. A single micro-organism can degrade both saturated and unsaturated chains with varying chain lengths. The alkyl chains are therefore completely degraded by micro-organisms with comparable potential.The hydrophilic moiety, dipropylene triamine is metabolised through ß-alanine, which also feeds into the central metabolism (Large, 1992). Dipropylene triamine (N-(3-aminopropyl)-1,3 propanediamine) is readily biodegradable (van Ginkel et al, 2010; Rothkopf and Bartha, 1984). Alkyl dipropylene triamines based on the biodegradation pathways of all moieties are therefore completely (ultimately) biodegradable. The ultimate biodegradation of Coco dipropylene triamine(C8-18dipropylene triamine)has been demonstrated in semi-continuously fed activated sludge (SCAS) units.
Based on the broad substrate specificity of micro-organisms degrading fatty amine derivatives with respect to the alkyl chain length it is unlikely that the biodegradability of these surfactants differs significantly with varying alkyl chain lengths. Biocidal effects explain negative results obtained in ready biodegradability tests. A Closed Bottle test carried out with Coco dipropylene triamine(C8-18dipropylene triamine)in the presence of silica gel did not lead to a false negative result and thus to a fair interpretation of the biodegradability. The adequate ready biodegradability test result obtained and the scientific evidence that consortia of polypropylene polyamines- and alkyl-utilizing microorganisms through a joint biodegradation pathway degrade all N-alkyl dipropylene triamines lead to the conclusion that all N-alkyl dipropylene triamines are readily biodegradable.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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