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Diss Factsheets
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EC number: 427-430-5 | CAS number: 54301-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2008-09-11 to 2008-11-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, OECD guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2007-01-12
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- As solubility surpasses 100mg/L, a solution containing 100 mg/L in dilution water was prepared. The resulting solution was clear and homogeneous. The pH of the solution was determined as 6.5.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Variety STRAUS
Strain: Berlin
Sex: female
Age: between 0 end 24 hours
Origin: Umweltbundesamt Berlin
Arrival of Strain: September, 27th 2007
Selection of the test system was made following the proposal of the guidelines.
Food: unicellular green algae, not during the test
Medium renewal: twice a week
Photo period: 16/8 hours, using neon tubes
T: 20 +/- 2°C - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 2.50 mmol/L
- Test temperature:
- 23.5 - 24.1 °C
- pH:
- from 7.2 to 7.7
- Dissolved oxygen:
- above 8.3 mg/L
- Details on test conditions:
- - Vessels: glass beakers, nominal volume 50 mL, tall shape
- Replicates: four vessels, each containing 20 mL test solution and five daphnia
- Control: four vessels, each containing 20 mL dilution water and five daphnia
- Feeding: none
- lighting: none
-Temperature: 20 +/-2°C - Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- 24h EC50 of K2Cr2O7 was determined at 0.79mg/L
Immobilisation in the controls was 10% at he most
The lowest concentration of dissolved oxygen at the end of the test was 8.4mg/L
The highest pH variation was 0.7 units.
The study can be considered valid - Results with reference substance (positive control):
- 24h EC50 of K2Cr2O7 was determined at 0.79 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- 24h NOEC= 100mg/L
48h NOEC= 100mg/L
24h EC50i> 100mg/L
48h EC50> 100 mg/L - Executive summary:
This study was performed in order to evaluate the toxic potential of Lipacide UG towards freshwater shrimp, using species Daphnia magna. D magna STRAUSS, which belongs to the family of crustacea, was chosen in the guideline as a typical part of zoo-plancton.
Twenty daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours, the immobilised daphnia were counted.
No animals were immobilised in the control. 10% of the animals were immobilised in the treatment, which was stated as not significant.
The 24h-EC50i of potassium dichromate was tested in a current reference test, the value was determined at 0.79mg/L, lying within the demanded range of 0.6 -2.1 mg/L.
at the start and at the end of the test, the content of the test item in the test solutions was determined. the recovery after 48 hours was 97% of the start concentration, the correlation between nominal and measured concentration was very good. Therefore, the determination of the biological results was based on the nominal concentration.
24h NOEC= 100mg/L
48h NOEC= 100mg/L
24h EC50i > 100mg/L
48h EC50i > 100 mg/L
Reference
Description of key information
In order to evaluate the toxic potential of the test substance towards freshwater shrimp, using species Daphnia magna an OECD Guideline 202( Daphnia sp.Acute Immobilisation test was performed towards freshwater shrimp.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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