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EC number: 241-460-4 | CAS number: 17439-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dihydrogen hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, hydrogen and titanium ions upon dissolution in the environment. However, hydrogen and titanium ions do not remain as such in solution, only fluoride ions do. The approach follows scenario 1 of the RAAF (ECHA 2017).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
fluoride salts (various)
Target
Dihydrogen hexafluorotitanate (CAS 17439-11-1)
3. ANALOGUE APPROACH JUSTIFICATION
The hydrogen ion attaches to a hydroxide ion to form a water molecule. The analysis of dissolved titanium levels in aquatic toxicity test solutions for algae, daphnia and fish according to OECD 201, 202 and 203 (Schlechtriem, 2013a, b; Teigeler, 2013) indicates that up to a loading of 100 mg/L dipotassium hexafluorotitanate, very low levels of titanium (often < 10% or even 5%) remain in solution at environmentally relevant pH while nearly all of the fluoride (often more than 95 %) could be recovered. Thus, regarding the environmental fate and toxicity of dihydrogen hexafluorotitanate, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across to potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion is justified.
4. DATA MATRIX
see attached read-across statement in section 13.2 - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 9.412 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: fluoride ion F-
- Basis for effect:
- mortality
- Details on results:
- In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
- Results with reference substance (positive control):
- No results reported.
- Reported statistics and error estimates:
- No results reported.
- Conclusions:
- In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water. Converted to the target substance this value corresponds to 9.412 mg/L.
- Executive summary:
In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water. Converted to the target substance this value corresponds to 9.412 mg/L.
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study summarised in ICD and EU RAR
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 21-day fish toxicity study
- GLP compliance:
- no
- Specific details on test material used for the study:
- Sodium fluoride is water soluble and will rapidly dissociate under the aqueous conditions of the test to form sodium and fluoride ions.
- Analytical monitoring:
- yes
- Details on sampling:
- No further details in review
- Vehicle:
- not specified
- Details on test solutions:
- No further details in review
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- No further details
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- Not relevant
- Hardness:
- soft water (12 mg CaCO3/l)
- Test temperature:
- Not reported
- pH:
- Not reported
- Dissolved oxygen:
- Not reported
- Salinity:
- Not reported
- Nominal and measured concentrations:
- Measured concentration
- Details on test conditions:
- The test was conducted in very soft (12 mg CaCO3/l) natural water with daily renewal of the test water.
- Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: fluoride ion F-
- Basis for effect:
- mortality
- Details on results:
- In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
- Results with reference substance (positive control):
- No results reported.
- Reported statistics and error estimates:
- No results reported.
- Conclusions:
- In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
- Executive summary:
In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
Referenceopen allclose all
In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
Description of key information
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of chronic toxicity data for fish of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified. The LC5 of 4 mg F/L derived for Oncoryhychus mykiss in a 21-d test with sodium fluoride (LC5 = 4 mg F/L ), results in an LC5 of 9.4 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 9.4 mg/L
Additional information
Dihydrogen hexafluorotitanate
For reasons of animal welfare, a repetition of the study with the test material is omitted and the existing data with potassium fluoride are considered sufficiently meaningful, also because the algae seems to be the most sensitive species based on the available data and thus there is no further benefit with regard to the estimation of the chronic toxicity of the test material.
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of chronic toxicity data for fish of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified (see below).
Sodium fluoride
In a 21 day test with Oncorhynchus mykiss, an LC5 value of 4 mg F/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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