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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 231-901-9 | CAS number: 7778-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented with minor deviations: no measured data was realized during the experiment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Differential effects of arsenite and arsenate to Drosophila melanogaster in a combined adult/developmental toxicity assay
- Author:
- Goldstein S.H and Babich H.
- Year:
- 1 989
- Bibliographic source:
- Bulletin of Environmental Contamination and Toxicology
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Drosophila melanogaster were maintained into vials containing unamended and amended medium with arsenite and arsenate. Survival flies were counted at the end of the exposure period (3 weeks).
- GLP compliance:
- no
- Application method:
- contact
Test material
- Reference substance name:
- Arsenate
- IUPAC Name:
- Arsenate
- Reference substance name:
- Arsenite
- IUPAC Name:
- Arsenite
- Details on test material:
- - Name of test material (as cited in study report): Arsenite and Arsenate
- Molecular formula (if other than submission substance): NaAsO2 and Na2HAsO4
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No details on properties of test surrogate or analogue material
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- No details on sampling
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- No details on preparation and application of test substrate
Test organisms
- Test organisms (species):
- Drosophila melanogaster
- Animal group:
- Diptera (fruit fly (small))
- Details on test organisms:
- TEST ORGANISM
- Common name: Drosophila (wild type Oregon -R)
- Source: no data
ACCLIMATION
- Acclimation period: no data
Study design
- Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 3 wk
- Remarks:
- The cultures were maintained for 7 days and the survival flies wree scored. Viable adult flies were then discarded and the vials were maintained for another 2 weeks.
- Post exposure observation period:
- No post exposure observation period
Test conditions
- Test temperature:
- 20°C
- Humidity:
- no data
- Photoperiod and lighting:
- no data
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): plastic vials (50 cm3)
- Amount of soil or substrate: no data
- No. of organisms per container (treatment): ten males and ten females
- No. of replicates per treatment group: 2
- No. of replicates per control: 2
OTHER TEST CONDITIONS
- Photoperiod: no data
- Light intensity: no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : survival, emergence
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.5
- Range finding study: no range finding study - Nominal and measured concentrations:
- 0, 0.1, 0.25, 0.5, 0.75, 1.0, 1.25, 1.5 and 2.0 mM (nominal concentrations)
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 wk
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.21 other: mM
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- development
- Remarks on result:
- other: additionnal results for arsenite exposure
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 0.54 other: mM
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: additionnal results for arsenite exposure
- Duration:
- 3 wk
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.45 other: mM
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- development
- Remarks on result:
- other: results based on arsenate concentrations
- Duration:
- 7 d
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.79 other: mM
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: results based on arsenate concentrations
- Details on results:
- After 4 days of exposure a reduction in survival of about 10% was noted for flies exposed to 0.25 to 0.75 mM arsenite or arsenate and of about 15 and 25% for flies exposed to 1.0mM arsenate and arsenite, respectively.
Reduction in the yield of adult flies in the developmental exposure was, apparently, not merely a reflection of the acute toxicities of the arsenics to the parental flies during their 7 day exposure. Thus, 0.25 mM arsenite or arsenate was not significantly toxic to the parental flies but in the developmental exposure assay these concentrations reduced the yield of the flies by about 60 and 40% respectively.
See the following figures in section 'Illustration (picture/graph)':
Figure 1: Survival of Drosophila melanogaster after 7 days of exposure to medium amended with varied concentrations of arsenite or arsenate
Figure 2: Reduction in the yield of Drosophila melanogaster by various concentrations of arsenite and arsenate - Results with reference substance (positive control):
- No results with reference substance
- Reported statistics and error estimates:
- The data points on the toxicity curves are presented as the arithmetic mean ± standard error of the mean (Figure 1 and 2)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Under the test conditions, the 7d-LC50 and the 3wk-EC50 were 0.54 mM and 0.21 mM respectively.
- Executive summary:
In a 7d-acute contact toxicity study and a 3wk developmental toxicity test, Drosophila melanogaster were exposed to arsenite and arsenate administered on instant drosophila medium at an application rate of 0 (control), 0.1, 0.25, 0.5, 0.75, 1.0, 1.25, 1.5 and 2.0 mM. The 7d-LC50 and 3wk-EC50 values were 0.54 mM and 0.21 mM rspectively, based on arsenite concentrations.
Results Synopsis:
Test organisms and test organism age: Drosophila melanogaster
Test type: contact
For acute contact:
7d-LC50: 0.54 mM
3wk-EC50: 0.21 mM
Endpoint(s) Effected: survival, emergence
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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