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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 223-772-2 | CAS number: 4065-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
Reference
Description of key information
The half-life of the test chemical was determined (Rensheng Zhuang et. al., 2013). The study was performed at a temperature of 25°C and pH 6.9, respectively. Initial test chemical conc. used was 10 mg/l. Experiment was performed with solutions of test chemical (10 mg L–1 in 0.01 M KH2PO4 + Na2HPO4 buffer (pH = 6.9). Firstly, 0.29 mL of 30% of NaOCl (sodium hypochlorite) or 0.4 mg of TCCA (trichloroisocyanuric acid) were added to 100 mL solution of test chemical and stirred in darkness at room temperature. Reaction mixtures were left to stand at room temperature for 24 h, after certain period of time reactions were stopped by addition of Na2SO3 and were afterwards analyzed by HPLC-DAD and UV-Vis spectrophotometer. The HPLC analyses were made on an Agilent 1100 Series chromatograph, coupled with DAD detector. The chromatographic separations were run on a Zorbax C8 column (4.6 mm ID × 250 mm, 5 μm) using a 60: 40 mixture of acetonitrile and acetic acid (pH 3) as the mobile phase. The column temperature was kept at 25 °C with the flow rate of 1.0 mL/min, injection volume 75 μL and the duration was 25 min with 5 min of post run. Test chemical and their chlorinated products were monitored at 240 nm. All the analyses were done in triplicates and are presented as mean values. Mass spectra were recorded on a 6224 Agilent Accurate-Mass TOF mass spectrometer. As the starting material was completely consumed in less than 15 min and there is almost no difference in the composition of reaction mixture in 15 min, 1 h or 24 h after the setup of the reaction. Thus, the half-life value of test chemical can be considered to be< 15 min. Based on this, it can be concluded that the test chemical was rapidly hydrolysable in water.
Key value for chemical safety assessment
Additional information
The half-life of the test chemical was determined (Rensheng Zhuang et. al., 2013). The study was performed at a temperature of 25°C and pH 6.9, respectively. Initial test chemical conc. used was 10 mg/l. Experiment was performed with solutions of test chemical (10 mg L–1 in 0.01 M KH2PO4 + Na2HPO4 buffer (pH = 6.9). Firstly, 0.29 mL of 30% of NaOCl (sodium hypochlorite) or 0.4 mg of TCCA (trichloroisocyanuric acid) were added to 100 mL solution of test chemical and stirred in darkness at room temperature. Reaction mixtures were left to stand at room temperature for 24 h, after certain period of time reactions were stopped by addition of Na2SO3 and were afterwards analyzed by HPLC-DAD and UV-Vis spectrophotometer. The HPLC analyses were made on an Agilent 1100 Series chromatograph, coupled with DAD detector. The chromatographic separations were run on a Zorbax C8 column (4.6 mm ID × 250 mm, 5 μm) using a 60: 40 mixture of acetonitrile and acetic acid (pH 3) as the mobile phase. The column temperature was kept at 25 °C with the flow rate of 1.0 mL/min, injection volume 75 μL and the duration was 25 min with 5 min of post run. Test chemical and their chlorinated products were monitored at 240 nm. All the analyses were done in triplicates and are presented as mean values. Mass spectra were recorded on a 6224 Agilent Accurate-Mass TOF mass spectrometer. As the starting material was completely consumed in less than 15 min and there is almost no difference in the composition of reaction mixture in 15 min, 1 h or 24 h after the setup of the reaction. Thus, the half-life value of test chemical can be considered to be< 15 min. Based on this, it can be concluded that the test chemical was rapidly hydrolysable in water.
Hydrolysis endpoint can also be considered for waiver as per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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