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Diss Factsheets
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EC number: 237-224-5 | CAS number: 13701-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption:
It is widely known that simple borate salts are readily absorbed via oral and inhalation routes of exposure, while dermal absorption over intact skin is considered very low (<0.5 %) in humans and experimental animals (SCCS, 2010).
Distribution:
Absorbed boron is distributed evenly and rapidly throughout the body and can be found in blood plasma, tissues and organs. Similar boron levels have been reported in soft tissues and blood plasma of both humans and experimental animals, while boron concentrations are observed higher in bone and lower in adipose tissues (HERA, 2005).
Metabolism:
It is widely accepted that prior to absorption in aqueous solutions at physiological pH and low concentrations that simple borate salts are rapidly hydrolysed to form undissociated boric acid as the dominant species. It is not expected that boric acid will be metabolised further, due to the strong boron-oxygen bonds (523 kJ/mol) (EMA, 2017).
Excretion:
Borate compounds are predominantly eliminated in urine as boric acid with a half-life of <24 hours in both humans and experimental animal (EMA, 2017).
References:
EMA (2017) Boric acid and borate used as excipients. Report published in support of the 'Questions and answers on boric acid and borates used as excipients in medicinal products for human use' (EMA/CHMP/619104/2013). European Medicines Agency.
HERA (2005) Substance: Boric Acid (CAS No 10043-35-3). Human and Environmental Risk Assessment on ingredients of Household Cleaning Products.
SCCS (2010) Opinion on boron compounds. Scientific Committee on Consumer Safety. 22 June, 2012. SCCS /1249/09. 1-28.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 0.5
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.