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Diss Factsheets
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EC number: 800-940-9 | CAS number: 35836-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: BCF value calculated by using a QSAR Method.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- calculations based on structure activity
- GLP compliance:
- no
- Remarks:
- (not applicable)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable - Radiolabelling:
- no
- Details on sampling:
- not applicable
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
- Test organisms (species):
- no data
- Details on test organisms:
- no data
- Route of exposure:
- other: QSAR
- Test type:
- other: QSAR
- Water / sediment media type:
- not specified
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Reference substance (positive control):
- not required
- Remarks:
- QSAR
- Details on estimation of bioconcentration:
- not applicable
- Type:
- other: log BCF
- Value:
- 2.465 dimensionless
- Remarks on result:
- other: regression-based estimate, BCFBAF v3.01
- Key result
- Type:
- BCF
- Value:
- 291.4 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: regression-based estimate, BCFBAF v3.01
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- BCF value of nopyl acetate (CAS 35836-72-7) is 291.4 L/kg wet-wt.
- Executive summary:
BCF value of nopyl acetate (CAS 35836 -72 -7) was assessed by using BCFBAF v3.01 software. The results with the regression-based estimate approach is the following:
Log BCF = 2.465 , BCF (L/kg) = 291.4
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: BCF value calculated by using a QSAR Method.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- calculations based on structure activity
- GLP compliance:
- no
- Remarks:
- (not applicable)
- Radiolabelling:
- no
- Details on sampling:
- not applicable
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
- Test organisms (species):
- no data
- Details on test organisms:
- No data
- Route of exposure:
- other: QSAR
- Test type:
- other: QSAR
- Water / sediment media type:
- not specified
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Reference substance (positive control):
- not required
- Remarks:
- QSAR
- Details on estimation of bioconcentration:
- not applicable
- Type:
- other: Log BCF
- Value:
- 2.546 dimensionless
- Remarks on result:
- other: Arnot-Gobas lower trophic (including biotransformation), BCFBAF v3.01 (logKow = 4.24)
- Key result
- Type:
- BCF
- Value:
- 351.8 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: Arnot-Gobas lower trophic (including biotransformation), BCFBAF v3.01 (logKow = 4.24)
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- BCF value of nopyl acetate (CAS 35836-72-7) is 351.8 L/kg wet-wt.
- Executive summary:
BCF value of nopyl acetate (CAS 35836 -72 -7) was assessed with BCFBAF v3.01 software. The results for the Arnot-Gobas lower trophic (including biotransformation) approach are the following:
Log BCF = 2.546, BCF (L/kg) = 351.8
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- not applicable
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: BCF value calculated by using a QSAR Method without QMRF developped.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- calculations based on structure activity
- GLP compliance:
- no
- Remarks:
- (not applicable)
- Radiolabelling:
- no
- Details on sampling:
- not applicable
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
- Test organisms (species):
- no data
- Details on test organisms:
- no data
- Route of exposure:
- other: QSAR
- Test type:
- other: QSAR
- Water / sediment media type:
- not specified
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Reference substance (positive control):
- not required
- Remarks:
- QSAR
- Details on estimation of bioconcentration:
- not applicable
- Type:
- other: log BCF
- Value:
- 2.904 dimensionless
- Remarks on result:
- other: TGD Part II, Chapter 3.8, equation (74) p. 126 (logKow = 4.24)
- Key result
- Type:
- BCF
- Value:
- 801.7 L/kg
- Basis:
- whole body w.w.
- Remarks on result:
- other: TGD Part II, Chapter 3.8, equation (74) p. 126 (logKow = 4.24)
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- no data
- Reported statistics:
- no data
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- BCF value of nopyl acetate (CAS 35836-72-7) is 801.7 L/kg wet-wt.
- Executive summary:
BCF value of nopyl acetate (CAS 35836 -72 -7) has been assessed by using the TGD Part II, Chapter 3.8, equation (74) p. 126.
The results are the following:
TGD Part II, Chapter 3.8, equation (74) p. 126 approach, log BCF = 2.904, BCF (L/kg) = 801.7
Referenceopen allclose all
Information for approaches from BCFBAF v3.01 software are given through attached files (QMRF and QPRF).
Information for approaches from BCFBAF v3.01 software are given through attached files (QMRF and QPRF).
The TGD (2003) equation has been assessed according to the OECD principles.
1. a defined endpoint:
bioconcentration Factor (BCF)
2. an unambiguous algorithm:
For a substance with a log Kow of 2 -6, the following linear relationship can be used as developed by Veith et al. (1979):
log BCF (fish) = 0.85*log Kow - 0.70.
For a substance with a log Kow higher than 6, a parabolic equation can be used:
log BCF (fish) = -0.20*log Kow² + 2.74*log Kow - 4.72.
3. a defined domain of applicability:
The model applicability domain consists of 2 parts: organic chemicals with log Kow of 2 -6 and organic chemicals with log Kow > 6.
4. appropriate measures of goodness-of-fit, robustness and predictivity:
n (number of data) = 55; R² (correlation coefficient) = 0.90
5. a mechanistic interpretation, if possible:
no data
Description of key information
The bioconcentration factor (BCF) was estimated by three QSAR models:
- BCFBAF v3.01 module of EPI Suite (v4.0) - Regression-based estimate
- BCF-BAF v3.01 module of EPI Suite (v4.0) (including biotransformation) - Arnot-Gobas lower trophic level
- A model described in Technical Guidance Risk Assessment (European Chemicals Bureau, 2003) - Part II, Chapter 3.8, equation (74) p. 126
The estimated fish BCF of nopyl acetate (CAS 35836-72-7) is 434.8 L/kg (geometric mean of results of the three QSAR models: 291.4, 351.8 and 801.72 L/kg).
Key value for chemical safety assessment
- BCF (aquatic species):
- 434.8 L/kg ww
Additional information
ECHA Guidance (chapter R.7.c) recommends to calculate the BCF endpoint value as the geometric mean of results obtained by means of QSAR models.
This geometric mean value is considered as the endpoint defining the substance potential for bioaccumulation and can be used as input parameter for environmental risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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