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EC number: 206-768-5 | CAS number: 373-61-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
BASF (1978) reported an acute oral LD50 value of about 510 mg/kg (ca. 380 ul/kg). Male and female Sprague-Dawley rats were administered via gavage doses of 100, 147, 215, 316, 464, 681, 1000 or 1470 ul/kg. No mortalities were seen at the 3 lower dose levels; 316 ul/kg 2/5 males within 14 days; 464 ul/kg 5/5 males and 4/5 females within 14 days; 681, 1000 and 1470 ul/kg 5/5 males and 5/5 females within 14 days. Clinical signs reported were dyspnea, apathy, lateral and ventral position, staggering, partial narcotic-like state with missing pain and cornea reflexes, exsiccosis, diarrhea and poor general state. Pathological findings noted were acute dilatation of the heart, acute congestive hyperemia, dilatation of the stomach with liquid content, extensive ulcerations in the glandular stomach, diffuse-reddened mucosa, atonic, diarrheic content (intestine).
No LC50 acute inhalation determination is available for dihydrogen bis(acetato)-O)difluoroborate. In an orientating inhalation hazard test with rats (BASF, 1978), test substance vapours were offered for 3 and 8 hours. After 3-hour exposure, no (0/12) animal died; after 8-hour exposure 1/12 animals died. Clinical signs observed after 8 hours were attempt to escape, severe irritation of the mucosa, intermittent breathing during exposure. Necropsy showed acute dilatation of the heart, acute congestive hyperemia and lobular pattern in the liver (animal that died).
BASF (1980) reported an acute inhalation toxicity study with acetic acid (CAS: 64-19-7). Male and female Sprague-Dawley rats were offered the following vapour concentrations: analytical (nominal): 0 (0) mg/L, 4.45 (9.0) mg/L, 6.96 (14.0) mg/L, 8.48 (14.0) mg/L, 9.91 (21.0) mg/L, 12.7 (21.0) mg/L, 15.4 (31.5) mg/L. Mortalities. 4.45/6.96 mg/L: 0/20; - 8.48 mg/L: 1/20 (female); - 9.91 mg/L: 13/20 (10 males, 3 females); - 12.7 mg/L 7/20 (5 males, 2 females); - 15.4 mg/L: 19/20 (10 males, 9 females); the animals died predominantly during the exposure or within 8 days after the exposure. Clinical signs: animals of all dose groups: attempts to escape, aqueous to reddish eye-nose secretion, salivation, eyelid closure, wiping of the snout, dyspnea, high stepping / staggering gait, cowering position, exhalation, fumy to milky clouded cornea, predominantly: necrosis at the tags, partially: necrosis at the snouts, hind-limbs; clinical signs were not so distinctive in the lower dose groups; the majority of the surviving animals still had necrosis at the tags at the end of the observation period. Pathology: Animals that died: heart: acute dilation, acute congestive hyperemia; - lung: acute exhalation, spot-like blood filling, in part edematous, emphysema; - kidney: bleached, brightened, hyperemia; - liver: hyperemia; sacrificed animals: nothing abnormal detected. The LC50 for male rats was > 8.5 - < 9.91 mg/l/4 h (analytical) and for female rats > 9.91 - < 15.4 mg/l/4 h (analytical).
Rusch et al. (1986) tested boron trifluoride dihydrate (CAS: 13319-75-0) for acute inhalation toxicity. Male and female rats were offered vapour concentrations of 1.01, 1.22, 1.32 and 1.54 mg/l for 4 hours (whole-body exposure). Deaths occurred in all dose levels: 9/10 at 1.54 mg/l, 8/10 at 1.32 mg/l, 2/10 at 1.22 mg/l, 3/10 at 1.01 mg/l. Clinical signs elicited by the exposures included dry and moist rales, gasping, excessive oral and nasal discharge and lacrimation. A decrease in liver and kidney weights was noted as pathological finding. The LC50 was 1210 mg/m3 for 4 hours (both sexes).
No data are available for acute dermal toxicity.
Justification for classification or non-classification
Due to the corrosivity of dihydrogen bis(acetato-O)difluoroborate, testing regarding acute oral, dermal and inhalation toxicity is not meaningful.
The structure-related test compound boron trifluoride is classified with T+ and R26 (EU) and Acute Tox. Cat. 2, H 330 (GHS). For test compound boron trifluoride dihydrate proposal for classification is Acute Tox. Cat. 4, H332 (GHS) and Xn, R20 (EU).
Classification proprosal for dihydrogen bis(acetato-O)difluoroborate: Xn; R 20/22 (EU); Acute Tox. Cat. 4; H302 + H332 (GHS)Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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